Monitoring Adverse Events during Seasonal Malaria Chemoprevention Campaigns for Children Aged 3 - 59 Months in Benin in 2023  

作　　者：Cyriaque Affoukou Rock Aïkpon Georgia Damiens Olaréwadjou Richard Biaou Boni Géraud Padonou William Houndjo Camille Houetohossou Elysé Sohizoun Thibaud Legba Aurore Ogouyemi Badirou Aguemon Cyriaque Affoukou;Rock Aïkpon;Georgia Damiens;Olaréwadjou Richard Biaou Boni;Géraud Padonou;William Houndjo;Camille Houetohossou;Elysé Sohizoun;Thibaud Legba;Aurore Ogouyemi;Badirou Aguemon(Community Health and Epidemiology Unit, Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin;National Malaria Control Program, Cotonou, Benin;Laboratory of Epidemiology of Chronic and Neurological Diseases (LEMACEN), Faculty of Health Sciences, University of Abomey-Calavi, Cotonou Benin;Ministry of Health, Cotonou, Benin)

机构地区：[1]Community Health and Epidemiology Unit, Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin [2]National Malaria Control Program, Cotonou, Benin [3]Laboratory of Epidemiology of Chronic and Neurological Diseases (LEMACEN), Faculty of Health Sciences, University of Abomey-Calavi, Cotonou Benin [4]Ministry of Health, Cotonou, Benin

出　　处：《Open Journal of Epidemiology》2024年第4期579-589,共11页流行病学期刊（英文）

摘　　要：Background: Seasonal malaria chemoprevention (SMC) is crucial for reducing the burden of malaria in children. However, adverse events (AEs) can affect treatment adherence and efficacy. This study assesses the prevalence of AEs associated with SMC and identifies factors associated with treatment discontinuation. Methods: A cross-sectional study of 3115 children receiving SMC was conducted. The study was conducted in two departments in northern Benin. The prevalence of AEs and factors associated with discontinuation of treatment were analyzed. Results: Among the children, 578 (18.6%, 95% CI: 17.2 - 19.9) reported AEs, mainly vomiting (63.5%), fever (43.8%) and diarrhea (23.0%). Boys (51.9%) had slightly more AEs than girls (48.1%). The prevalence of AEs was higher in rural areas (64.0%) than in urban areas (36.0%). Only 2.8% of children stopped taking SMC because of AEs. There was no significant association between AEs and discontinuation of SMC (p = 0.608). Children referred to health centers for management of AEs were less likely to discontinue treatment (p = 0.015). Conclusion: AEs were common, but the rate of discontinuation of SMC due to AEs was low, indicating good treatment tolerance. Effective management of AEs in health centers reduces treatment interruptions.Background: Seasonal malaria chemoprevention (SMC) is crucial for reducing the burden of malaria in children. However, adverse events (AEs) can affect treatment adherence and efficacy. This study assesses the prevalence of AEs associated with SMC and identifies factors associated with treatment discontinuation. Methods: A cross-sectional study of 3115 children receiving SMC was conducted. The study was conducted in two departments in northern Benin. The prevalence of AEs and factors associated with discontinuation of treatment were analyzed. Results: Among the children, 578 (18.6%, 95% CI: 17.2 - 19.9) reported AEs, mainly vomiting (63.5%), fever (43.8%) and diarrhea (23.0%). Boys (51.9%) had slightly more AEs than girls (48.1%). The prevalence of AEs was higher in rural areas (64.0%) than in urban areas (36.0%). Only 2.8% of children stopped taking SMC because of AEs. There was no significant association between AEs and discontinuation of SMC (p = 0.608). Children referred to health centers for management of AEs were less likely to discontinue treatment (p = 0.015). Conclusion: AEs were common, but the rate of discontinuation of SMC due to AEs was low, indicating good treatment tolerance. Effective management of AEs in health centers reduces treatment interruptions.

关 键 词：SMC Adverse Events Treatment Adherence BENIN 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]