The effect of melatonin in functional heartburn: A randomized, placebo-controlled clinical trial  

作　　者：Patrick P. Basu Hemanth Hempole Nitya Krishnaswamy Niraj J. Shah Mark M. Aloysius 

机构地区：[1]Columbia University College of Physicians and Surgeons, New York, USA [2]James J. Peters VA Medical Center, Mount Sinai School of Medicine, New York, USA [3]King’s County Hospital, New York, USA [4]North Shore University Hospital at Forest Hills, Forest Hills, USA

出　　处：《Open Journal of Gastroenterology》2014年第2期56-61,共6页肠胃病学期刊（英文）

摘　　要：Background: Melatonin is a safe and effective treatment for patients with functional pain and gastrointestinal disorders. Objective: To evaluate the efficacy and safety of melatonin for 3 months in patients with functional heartburn. Methods: In the randomized, placebo-controlled pilot study, patients with functional heartburn were treated with omeprazole 20 mg before breakfast and randomized to receive either melatonin 6 mg (n = 20), nortripty line 25 mg (n = 20), or placebo (n = 20) at bedtime for 3 months. Gastroesophageal Reflux Disease-Health-Related Quality of Life (GERD-HRQOL) scores were assessed at baseline and at the end of the study. Results: Melatonin improved GERD-HRQOL scores compared with nortriptyline (P = 0.0015) and placebo (P < 0.0001). Fewer adverse events were reported by patients receiving melatonin compared with those receiving nortriptyline or placebo. Conclusions: Melatonin was a safe and effective treatment for functional heartburn.Background: Melatonin is a safe and effective treatment for patients with functional pain and gastrointestinal disorders. Objective: To evaluate the efficacy and safety of melatonin for 3 months in patients with functional heartburn. Methods: In the randomized, placebo-controlled pilot study, patients with functional heartburn were treated with omeprazole 20 mg before breakfast and randomized to receive either melatonin 6 mg (n = 20), nortripty line 25 mg (n = 20), or placebo (n = 20) at bedtime for 3 months. Gastroesophageal Reflux Disease-Health-Related Quality of Life (GERD-HRQOL) scores were assessed at baseline and at the end of the study. Results: Melatonin improved GERD-HRQOL scores compared with nortriptyline (P = 0.0015) and placebo (P < 0.0001). Fewer adverse events were reported by patients receiving melatonin compared with those receiving nortriptyline or placebo. Conclusions: Melatonin was a safe and effective treatment for functional heartburn.

关 键 词：MELATONIN Functional HEARTBURN NORTRIPTYLINE HRQOL 

分 类 号：R5[医药卫生—内科学]