Hepatotoxicity Induced by High Dose of Methylprednisolone Therapy in a Patient with Multiple Sclerosis: A Case Report and Brief Review of Literature  

作　　者：Mohamed A. H. Kadle Natalia V. Mazurchik Mohamed A. H. Kadle;Natalia V. Mazurchik(Center for the Study of the Liver, Peoples Friendship University of Russia, Moscow, Russia)

机构地区：[1]Center for the Study of the Liver, Peoples Friendship University of Russia, Moscow, Russia

出　　处：《Open Journal of Gastroenterology》2016年第5期146-150,共5页肠胃病学期刊（英文）

摘　　要：Toxic hepatitis due to drugs is an important and frequent drug adverse reaction in clinical practice. Here, we report a case of high dose methylprednisolone-induced acute hepatitis in a 51-year-old woman that suffers from multiple sclerosis while steroids are usually safe drugs with regards to liver injury and even they are the treatment choice of autoimmune hepatitis, but the literatures about corticosteroids showed are not entirely safe to liver injury and they have occasionally linked to hepatotoxicity. Although recent reports have demonstrated that prednisolone may cause hepatitis. This case report includes a brief review of the relevant literature on corticosteroids-induced hepatitis that is presented.Toxic hepatitis due to drugs is an important and frequent drug adverse reaction in clinical practice. Here, we report a case of high dose methylprednisolone-induced acute hepatitis in a 51-year-old woman that suffers from multiple sclerosis while steroids are usually safe drugs with regards to liver injury and even they are the treatment choice of autoimmune hepatitis, but the literatures about corticosteroids showed are not entirely safe to liver injury and they have occasionally linked to hepatotoxicity. Although recent reports have demonstrated that prednisolone may cause hepatitis. This case report includes a brief review of the relevant literature on corticosteroids-induced hepatitis that is presented.

关 键 词：Toxic Hepatitis METHYLPREDNISOLONE Multiple Sclerosis 

分 类 号：R57[医药卫生—消化系统]