The Combined Diagnostic Accuracy of Serum Alpha Fetoprotein and Des-Gamma Carboxyprothrombin in Hepatocellular Carcinoma among Chronic Liver Disease Patients in Ilorin  

作　　者：A. M. Aliyu A. B. Olokoba M. O. Bojuwoye K. C. Okonkwo A. M. Aliyu;A. B. Olokoba;M. O. Bojuwoye;K. C. Okonkwo(Department of Internal Medicine, College of Medicine, University of Ilorin, Ilorin, Nigeria;Department of Internal Medicine, Federal Medical Centre, Owo, Nigeria)

机构地区：[1]Department of Internal Medicine, College of Medicine, University of Ilorin, Ilorin, Nigeria [2]Department of Internal Medicine, Federal Medical Centre, Owo, Nigeria

出　　处：《Open Journal of Gastroenterology》2021年第12期255-274,共20页肠胃病学期刊（英文）

摘　　要：<strong>Introduction</strong><span><span><span style="font-family:;" "=""> <strong>:</strong></span></span></span><span><span><span style="font-family:;" "="">Chronic liver disease (CLD) is a disease of public health importance. CLD is<b> </b>defined as a clinical syndrome of liver disease lasting for at least six months with histology showing varying degree of hepatocellular necro-inflammation and fibrosis with or without neoplastic transformation. The disease is a spectrum that manifests initially as chronic hepatitis which may progress to liver cirrhosis and ultimately hepatocellular carcinoma (HCC).</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">The current practice in the field of Gastroenterology has shifted from invasive methods of diagnosing HCC to non-invasive methods using tumor biomarkers. Various biomarkers of HCC have been proposed, but the largest body of evidence exists with<span> alpha-fetoprotein</span> (AFP). Most of the studies on the combined diagnostic accuracy of AFP and des</span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "="">gamma</span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "="">carboxyprothrombin (DCP) were done in other populations outside Nigeria. It is necessary to determine the combined diagnostic accuracy of the two tumor markers for early detection of HCC in North-central Nigeria.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><b><span style="font-family:;" "="">Materials and Methods</span></b></span></span><span><span><b><span style="font-family:;" "="">: </span></b></span></span><span><span><span style="font-family:;" "="">This study was a cross-sectional study and ethical clearance was obtained from the<b> </b>ethical and research committee of UITH, Ilorin. A total of 190 participants c<strong>Introduction</strong><span><span><span style="font-family:;" "=""> <strong>:</strong></span></span></span><span><span><span style="font-family:;" "="">Chronic liver disease (CLD) is a disease of public health importance. CLD is<b> </b>defined as a clinical syndrome of liver disease lasting for at least six months with histology showing varying degree of hepatocellular necro-inflammation and fibrosis with or without neoplastic transformation. The disease is a spectrum that manifests initially as chronic hepatitis which may progress to liver cirrhosis and ultimately hepatocellular carcinoma (HCC).</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">The current practice in the field of Gastroenterology has shifted from invasive methods of diagnosing HCC to non-invasive methods using tumor biomarkers. Various biomarkers of HCC have been proposed, but the largest body of evidence exists with<span> alpha-fetoprotein</span> (AFP). Most of the studies on the combined diagnostic accuracy of AFP and des</span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "="">gamma</span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "="">carboxyprothrombin (DCP) were done in other populations outside Nigeria. It is necessary to determine the combined diagnostic accuracy of the two tumor markers for early detection of HCC in North-central Nigeria.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><b><span style="font-family:;" "="">Materials and Methods</span></b></span></span><span><span><b><span style="font-family:;" "="">: </span></b></span></span><span><span><span style="font-family:;" "="">This study was a cross-sectional study and ethical clearance was obtained from the<b> </b>ethical and research committee of UITH, Ilorin. A total of 190 participants c

关 键 词：Necro-Inflammation Liver Cirrhosis Hepatocellular Carcinoma Alpha Fetoprotein Des-Gamma-Carboxyprothrombin Enzyme-Linked Immunoassay PERCUTANEOUS Tumor Markers 

分 类 号：R73[医药卫生—肿瘤]