Hereditary Immunity and the Origin of Atherosclerosis  

作　　者：Sergey N. Rumyantsev Vil K. Gerasimov Jergy Grzezczuk Roman A. Aron Nataly F. Avrova Irina V. Belyakova Ludmila V. Bobrakova Kirill F. Dubrov Ludmila V. Perkus Vladimir F. Pospelov Nina M. Rogacheva Nikolay P. Shabalov 

机构地区：[1]Department of Evolutionary Immunology, Andent, Inc., Jersey City, USA

出　　处：《Open Journal of Immunology》2014年第1期14-21,共8页免疫学期刊（英文）

摘　　要：This paper tries to present new confirmation for the opinion about the infectious origin of atherosclerosis from the viewpoint of the current knowledge of hereditary immunity. The performed integrative investigation included the reinterpretation of known clinical and epidemiological observations, supported by immunological, molecular ecological, genetic, and genomic discoveries. The revealed body of firstly achieved information is compatible with the concept that infectious agents contribute the clue step to the development of atherosclerosis over its initial stage performed during the triggering of the arterial endothelial wall by the molecular agent of proposed infectious origin.This paper tries to present new confirmation for the opinion about the infectious origin of atherosclerosis from the viewpoint of the current knowledge of hereditary immunity. The performed integrative investigation included the reinterpretation of known clinical and epidemiological observations, supported by immunological, molecular ecological, genetic, and genomic discoveries. The revealed body of firstly achieved information is compatible with the concept that infectious agents contribute the clue step to the development of atherosclerosis over its initial stage performed during the triggering of the arterial endothelial wall by the molecular agent of proposed infectious origin.

关 键 词：EPIDEMIC Spread HETEROZYGOSITY HOMOZYGOSITY Immune MOSAICISM Integrative Approach PLAQUE Formation 

分 类 号：R73[医药卫生—肿瘤]