Rare Aggressive Form of Multiple Myeloma with Diffuse Osteosclerosis and Elevated CA 15-3 Levels  

作　　者：Dally Najib Daniel Talmud Saher Srour Rola Khamisy-Farah Raymond Farah Dally Najib;Daniel Talmud;Saher Srour;Rola Khamisy-Farah;Raymond Farah(Department of Hematology, Ziv Medical Center, Zefat, Israel;Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel;Department of Internal Medicine, Ziv Medical Center, Zefat, Israel;Department of Radiology, Ziv Medical Center, Zefat, Israel;Clalit Health Service, Akko, Israel)

机构地区：[1]Department of Hematology, Ziv Medical Center, Zefat, Israel [2]Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel [3]Department of Internal Medicine, Ziv Medical Center, Zefat, Israel [4]Department of Radiology, Ziv Medical Center, Zefat, Israel [5]Clalit Health Service, Akko, Israel

出　　处：《Open Journal of Internal Medicine》2016年第1期11-14,共4页内科学期刊（英文）

摘　　要：We report the case of a 56-year-old female who had recently been examined for back and epigastric pain, and was diagnosed in the internal medicine ward as having an aggressive rare form of multiple myeloma with diffuse osteoblastic bone lesions. She also had high levels of breast tumor marker (CA 15-3), severe tumor lysis syndrome, and pleural and central nervous system involvement. A few cases of multiple myeloma with diffuse osteosclerosis that are not part of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changeshave) have been described. None of these cases were as aggressive as our case. To our knowledge it is the first report describing an elevation in CA 15-3 in conjunction with multiple myeloma.We report the case of a 56-year-old female who had recently been examined for back and epigastric pain, and was diagnosed in the internal medicine ward as having an aggressive rare form of multiple myeloma with diffuse osteoblastic bone lesions. She also had high levels of breast tumor marker (CA 15-3), severe tumor lysis syndrome, and pleural and central nervous system involvement. A few cases of multiple myeloma with diffuse osteosclerosis that are not part of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changeshave) have been described. None of these cases were as aggressive as our case. To our knowledge it is the first report describing an elevation in CA 15-3 in conjunction with multiple myeloma.

关 键 词：Multiple Myeloma OSTEOSCLEROSIS CA 15-3 Pleural Effusion 

分 类 号：R73[医药卫生—肿瘤]