Garenoxacin Prophylaxis for Febrile Neutropenia after Chemotherapy in Hematological Malignancies  

作　　者：Nobuhiko Nakamura Takeshi Hara Soranobu Ninomiya Yuhei Shibata Takuro Matsumoto Hiroshi Nakamura Junichi Kitagawa Yasuhito Nannya Masahito Shimizu Nobuo Murakami Hisashi Tsurumi Nobuhiko Nakamura;Takeshi Hara;Soranobu Ninomiya;Yuhei Shibata;Takuro Matsumoto;Hiroshi Nakamura;Junichi Kitagawa;Yasuhito Nannya;Masahito Shimizu;Nobuo Murakami;Hisashi Tsurumi(Department of Hematology, Gifu University Graduate School of Medicine, Gifu, Japan)

机构地区：[1]Department of Hematology, Gifu University Graduate School of Medicine, Gifu, Japan

出　　处：《Open Journal of Internal Medicine》2016年第4期128-138,共11页内科学期刊（英文）

摘　　要：Background: Febrile neutropenia is one of the most serious adverse events in patients with hematological malignancies and chemotherapy. The routine use of fluoroquinolone prophylaxis in patients with hematological malignancies is controversial. Therefore, we prospectively evaluated the efficacy and safety of prophylactic use of garenoxacin for febrile neutropenia. Patients and Methods: Consecutive adult patients with hematological malignancies who were at risk for chemotherapy-induced neutropenia lasting more than seven days were eligible for present study. They received oral garenoxacin (400 mg daily) from the neutrophil count decreased to less than 1000/μl and continued until the neutropenia had resolved. The primary endpoint was incidence of febrile neutropenia, and the secondary endpoints were the type and incidence of adverse events. Results: We enrolled 46 consecutive patients (median age, 59 years). The underlying diseases comprised acute myeloid leukemia (n = 17), acute lymphoblastic leukemia (n = 3), malignant lymphoma (n = 23), and multiple myeloma (n = 3). There were 23 febrile neutropenia episodes and 2 episodes of bacteremia. There were no grade 3 or 4 adverse events;however serum creatinine levels were significantly elevated after garenoxacin administration. The overall prophylactic efficacy of garenoxacin was 50%, and there were no infection-related deaths. Conclusions: Prophylactic use of garenoxacin is effective and safe in patients with hematological malignancies. (Clinical trial registration number: UMIN000004979).Background: Febrile neutropenia is one of the most serious adverse events in patients with hematological malignancies and chemotherapy. The routine use of fluoroquinolone prophylaxis in patients with hematological malignancies is controversial. Therefore, we prospectively evaluated the efficacy and safety of prophylactic use of garenoxacin for febrile neutropenia. Patients and Methods: Consecutive adult patients with hematological malignancies who were at risk for chemotherapy-induced neutropenia lasting more than seven days were eligible for present study. They received oral garenoxacin (400 mg daily) from the neutrophil count decreased to less than 1000/μl and continued until the neutropenia had resolved. The primary endpoint was incidence of febrile neutropenia, and the secondary endpoints were the type and incidence of adverse events. Results: We enrolled 46 consecutive patients (median age, 59 years). The underlying diseases comprised acute myeloid leukemia (n = 17), acute lymphoblastic leukemia (n = 3), malignant lymphoma (n = 23), and multiple myeloma (n = 3). There were 23 febrile neutropenia episodes and 2 episodes of bacteremia. There were no grade 3 or 4 adverse events;however serum creatinine levels were significantly elevated after garenoxacin administration. The overall prophylactic efficacy of garenoxacin was 50%, and there were no infection-related deaths. Conclusions: Prophylactic use of garenoxacin is effective and safe in patients with hematological malignancies. (Clinical trial registration number: UMIN000004979).

关 键 词：Febrile Neutropenia PROPHYLAXIS GARENOXACIN Hematological Malignancies 

分 类 号：R73[医药卫生—肿瘤]