Brain MRI Findings in Infantile Spasm: Outcome Correlations in a Patient Cohort  

作　　者：Alireza Khatami Erick Sell Mohamed Aggag Elka Miller Alireza Khatami;Erick Sell;Mohamed Aggag;Elka Miller(Department of Medical Imaging, Children’s Hospital of Eastern Ontario, University of Ottawa, Ontario, Canada;Department of Pediatrics, Division of Neurology, Children’s Hospital of Eastern Ontario, University of Ottawa, Ontario, Canada)

机构地区：[1]Department of Medical Imaging, Children’s Hospital of Eastern Ontario, University of Ottawa, Ontario, Canada [2]Department of Pediatrics, Division of Neurology, Children’s Hospital of Eastern Ontario, University of Ottawa, Ontario, Canada

出　　处：《Open Journal of Medical Imaging》2016年第3期80-92,共14页医学影像期刊（英文）

摘　　要：Background: Infantile spasm is a type of pediatric seizure often associated with a negative prognosis. The aim of this study was to evaluate the role of Magnetic Resonance Imaging (MRI) in categorization and neurodevelopmental outcomes in children with infantile spasm. Materials and Methods: A retrospective study of the clinical charts and MRI findings of infants diagnosed with infantile spasm between December 2007 and February 2014. Results: A total of 26 children (16 males;1.6/1) were included: 8 of unknown etiology and 18 with a genetic/structural-metabolic causes. Unknown etiology cases revealed normal brain MRI in 5/8 (62.5%). In the genetic/ structural-metabolic group, only 2/18 (11.1%) had normal imaging. Abnormal imaging findings significantly correlated with genetic/structural-metabolic infantile spasm which had unfavorable neurodevelopmental outcome. Conclusion: Neuroimaging conveys substantial information to the further categorization of children with infantile spasm, providing not only relevant information of the underlying cause but also the prediction of the neurodevelopmental outcome.Background: Infantile spasm is a type of pediatric seizure often associated with a negative prognosis. The aim of this study was to evaluate the role of Magnetic Resonance Imaging (MRI) in categorization and neurodevelopmental outcomes in children with infantile spasm. Materials and Methods: A retrospective study of the clinical charts and MRI findings of infants diagnosed with infantile spasm between December 2007 and February 2014. Results: A total of 26 children (16 males;1.6/1) were included: 8 of unknown etiology and 18 with a genetic/structural-metabolic causes. Unknown etiology cases revealed normal brain MRI in 5/8 (62.5%). In the genetic/ structural-metabolic group, only 2/18 (11.1%) had normal imaging. Abnormal imaging findings significantly correlated with genetic/structural-metabolic infantile spasm which had unfavorable neurodevelopmental outcome. Conclusion: Neuroimaging conveys substantial information to the further categorization of children with infantile spasm, providing not only relevant information of the underlying cause but also the prediction of the neurodevelopmental outcome.

关 键 词：Infantile Spasm Magnetic Resonance Imaging Brain Imaging INFANT VIGABATRIN 

分 类 号：R73[医药卫生—肿瘤]