Hypergonadotrophic Hypogonadism with Cerebellar Ataxia in a Twenty-Six-Year-Old Female: A Case Report  

作　　者：Bibiana I. Oti Geoffrey Okorie Peter Chime Ethel Chime Birinus Ezeala-Adikaibe Casmir Orjioke Fintan Ekochin Michael C. Abonyi Bibiana I. Oti;Geoffrey Okorie;Peter Chime;Ethel Chime;Birinus Ezeala-Adikaibe;Casmir Orjioke;Fintan Ekochin;Michael C. Abonyi(Enugu State University Teaching Hospital, Enugu, Nigeria;University of Nigeria Teaching Hospital, Ituku-Ozalla, Nigeria)

机构地区：[1]Enugu State University Teaching Hospital, Enugu, Nigeria [2]University of Nigeria Teaching Hospital, Ituku-Ozalla, Nigeria

出　　处：《Open Journal of Modern Neurosurgery》2024年第1期83-90,共8页现代神经外科学进展（英文）

摘　　要：Gordon Holmes Syndrome is a rare inherited disease characterized by both neurological and reproductive signs and symptoms. Most patients develop neurologic challenges in early adulthood and cerebellar ataxia occurs as the disease progresses. In the majority of patients, hypogonadism is hypogonadotropic but rarely hypergonadotropic. We report a case of a 26-year-old female in Nigeria, with hypergonadotropic hypogonadism and cerebellar atrophy from a non-consanguineous marriage and no family history.Gordon Holmes Syndrome is a rare inherited disease characterized by both neurological and reproductive signs and symptoms. Most patients develop neurologic challenges in early adulthood and cerebellar ataxia occurs as the disease progresses. In the majority of patients, hypogonadism is hypogonadotropic but rarely hypergonadotropic. We report a case of a 26-year-old female in Nigeria, with hypergonadotropic hypogonadism and cerebellar atrophy from a non-consanguineous marriage and no family history.

关 键 词：Gordon Holmes Syndrome Hypergonadotrophic Hypogonadism Cerebellar Ataxia Neuroendocrine Disorder 

分 类 号：R73[医药卫生—肿瘤]