Thrombotic Events in Patients with Antiphospholipid Syndrome: A Single Center Study  

作　　者：H. Khachatryan L. Sahakyan G. Sargsyan S. Danelyan I. Karapetyan S. Petrosyan N. Ghukasyan A. Stepanyan A. Poghosyan A. Harutyunyan K. Ginosyan K. Arustamyan G. Tamamyan N. Sargsyan H. Khachatryan;L. Sahakyan;G. Sargsyan;S. Danelyan;I. Karapetyan;S. Petrosyan;N. Ghukasyan;A. Stepanyan;A. Poghosyan;A. Harutyunyan;K. Ginosyan;K. Arustamyan;G. Tamamyan;N. Sargsyan(Hemophilia and Thrombosis Center, Yerevan, Armenia;Armenian Hematology Center aft. Prof. R. Yeolyan, Yerevan, Armenia;Department of Pediatric Oncology and Hematology, Yerevan State Medical University, Yerevan, Armenia;Department of Obstetrics and Gynecology Beglaryan Medical Center, Yerevan, Armenia;Erebouni Medical Center, Yerevan State Medical University, Yerevan, Armenia;Department of Rheumatology, Yerevan State Medical University, Yerevan, Armenia;Research Center of Maternal and Child Health Protection, Yerevan, Armenia)

机构地区：[1]Hemophilia and Thrombosis Center, Yerevan, Armenia [2]Armenian Hematology Center aft. Prof. R. Yeolyan, Yerevan, Armenia [3]Department of Pediatric Oncology and Hematology, Yerevan State Medical University, Yerevan, Armenia [4]Department of Obstetrics and Gynecology Beglaryan Medical Center, Yerevan, Armenia [5]Erebouni Medical Center, Yerevan State Medical University, Yerevan, Armenia [6]Department of Rheumatology, Yerevan State Medical University, Yerevan, Armenia [7]Research Center of Maternal and Child Health Protection, Yerevan, Armenia

出　　处：《Open Journal of Obstetrics and Gynecology》2023年第3期654-661,共8页妇产科期刊（英文）

摘　　要：Background: There is limited literature regarding risk factors for development of thrombosis and long-term thrombotic outcomes in Armenian APS patients. The aim of the study is to identify patients with APS with thrombotic complications and to evaluate the epidemiological statistics of thrombosis and thrombophilia and their complications in Armenia. Methods: We analyzed medical records of Patients with APS from January 2018 to December 2021 treated at the Armenian Thrombosis and Hemostasis Center was enrolled. Results: Both acquired and hereditary thrombophilia increase the risk of thrombosis. Thrombophilia was present in 61.5% of 123 patients. It was found that 38 pregnant women with thrombosis had a family history of VTE, myocardial infarction or stroke in the next of kin under 50 years of age. The prevalence of this history was 31.4% (11 patients) compared to 68.6% (27 patients), who did not have 41.6% of postpartum thrombotic events up to two months postpartum. Conclusion: Thrombosis in pregnancy is a redoubtable complication requiring an excellent cooperation between the obstetrician and hematologist. Clear detection of thrombosis in APS patients in all types allows to accurately predicting the method and duration of anticoagulant treatment and to prevent thrombotic complications.Background: There is limited literature regarding risk factors for development of thrombosis and long-term thrombotic outcomes in Armenian APS patients. The aim of the study is to identify patients with APS with thrombotic complications and to evaluate the epidemiological statistics of thrombosis and thrombophilia and their complications in Armenia. Methods: We analyzed medical records of Patients with APS from January 2018 to December 2021 treated at the Armenian Thrombosis and Hemostasis Center was enrolled. Results: Both acquired and hereditary thrombophilia increase the risk of thrombosis. Thrombophilia was present in 61.5% of 123 patients. It was found that 38 pregnant women with thrombosis had a family history of VTE, myocardial infarction or stroke in the next of kin under 50 years of age. The prevalence of this history was 31.4% (11 patients) compared to 68.6% (27 patients), who did not have 41.6% of postpartum thrombotic events up to two months postpartum. Conclusion: Thrombosis in pregnancy is a redoubtable complication requiring an excellent cooperation between the obstetrician and hematologist. Clear detection of thrombosis in APS patients in all types allows to accurately predicting the method and duration of anticoagulant treatment and to prevent thrombotic complications.

关 键 词：Thrombotic Complications THROMBOPHILIA Antiphospholipid Syndrome 

分 类 号：R73[医药卫生—肿瘤]