Cyclopia Associated with Sexual Ambiguity Discovered at the Birth of a Newborn Whose Mother Contracted COVID-19 in Early Pregnancy: A Rare Case at the Teaching Hospital of Angre (ABIDJAN)  

作　　者：Koffi Soh Victor Adjoby Cassou Roland Effoh N’drin Denis Kouakou-Kouraogo Ramata Akobé Privat Loba Okoin Paul José Houphouet-Mwandji Blanche Carine Koffi Soh Victor;Adjoby Cassou Roland;Effoh N’drin Denis;Kouakou-Kouraogo Ramata;Akobé Privat;Loba Okoin Paul José;Houphouet-Mwandji Blanche Carine(Department of Obstetrics and Gynecology, Teaching Hospital of Angr, Abidjan, Cte dIvoire;Faculty of Medicine, University Felix-Houphouet-Boigny, Abidjan, Cte dIvoire)

机构地区：[1]Department of Obstetrics and Gynecology, Teaching Hospital of Angr, Abidjan, Cte dIvoire [2]Faculty of Medicine, University Felix-Houphouet-Boigny, Abidjan, Cte dIvoire

出　　处：《Open Journal of Obstetrics and Gynecology》2024年第10期1556-1560,共5页妇产科期刊（英文）

摘　　要：Cyclopia is a rare congenital brain malformation frequently associated with facial anomalies. It is characterized by the presence of a single eye with varying degrees of doubling of the intrinsic ocular structures located in the middle of the face. It is the most severe facial expression of holoprosencephaly. Its aetiology is still poorly understood, but several factors could play a role in its occurrence, including certain viruses contracted during pregnancy. Obstetrical ultrasound has made antenatal diagnosis and the search for associated malformations possible. This diagnosis must be made antenatally because the prognosis is poor, hence the decision to terminate the pregnancy. We report a case of cyclopia associated with ambiguity of the external genitalia, discovered intraoperatively in a patient with poor prenatal follow-up, in whom a coronavirus infection (COVID-19) had been diagnosed in early pregnancy.Cyclopia is a rare congenital brain malformation frequently associated with facial anomalies. It is characterized by the presence of a single eye with varying degrees of doubling of the intrinsic ocular structures located in the middle of the face. It is the most severe facial expression of holoprosencephaly. Its aetiology is still poorly understood, but several factors could play a role in its occurrence, including certain viruses contracted during pregnancy. Obstetrical ultrasound has made antenatal diagnosis and the search for associated malformations possible. This diagnosis must be made antenatally because the prognosis is poor, hence the decision to terminate the pregnancy. We report a case of cyclopia associated with ambiguity of the external genitalia, discovered intraoperatively in a patient with poor prenatal follow-up, in whom a coronavirus infection (COVID-19) had been diagnosed in early pregnancy.

关 键 词：CYCLOPIA HOLOPROSENCEPHALY Congenital Malformation COVID-19 

分 类 号：R73[医药卫生—肿瘤]