A Case Report of Multiple Cylindroma with Immunohistochemical Features  

作　　者：Naoki Watanabe Kana Kawase Chisato Tawada Kazufumi Yoneda Kuniaki Hirai Ayumi Niwa Takuji Tanaka Naoki Watanabe;Kana Kawase;Chisato Tawada;Kazufumi Yoneda;Kuniaki Hirai;Ayumi Niwa;Takuji Tanaka(Department of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, Gifu City, Japan;Department of Dermatology, Gifu Municipal Hospital, Gifu City, Japan;Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Japan)

机构地区：[1]Department of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, Gifu City, Japan [2]Department of Dermatology, Gifu Municipal Hospital, Gifu City, Japan [3]Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Japan

出　　处：《Open Journal of Pathology》2016年第3期134-139,共7页病理学期刊（英文）

摘　　要：Cylindroma is a benign skin appendageal tumor arising from pluripotent stem cells in the follicle. Multiple cylindroma typically occurs as a component of Brooke-Spiegler syndrome or as the only skin lesion of familial cylindromatosis. We herein report an unusual case of multiple cylindroma involving the trunk without any other features of Brooke-Spiegler syndrome and no family history supporting the possibility of familial cylindromatosis. Immunohistochemical features of CYLD and NF-κB, which are involved in the pathogenesis of cylindroma, in the tumors are also presented.Cylindroma is a benign skin appendageal tumor arising from pluripotent stem cells in the follicle. Multiple cylindroma typically occurs as a component of Brooke-Spiegler syndrome or as the only skin lesion of familial cylindromatosis. We herein report an unusual case of multiple cylindroma involving the trunk without any other features of Brooke-Spiegler syndrome and no family history supporting the possibility of familial cylindromatosis. Immunohistochemical features of CYLD and NF-κB, which are involved in the pathogenesis of cylindroma, in the tumors are also presented.

关 键 词：Multiple Cylindroma IMMUNOHISTOCHEMISTRY CYLD NF-ΚB 

分 类 号：R73[医药卫生—肿瘤]