A Case of Ewing’s Sarcoma Arising in the Cervical Spine with an Elevation of Serum ProGRP  

作　　者：Ryogo Aoki Yoshikazu Ikoma Asuka Ohashi Riyoko Niwa Fumumasa Etori Masashi Matsuyama Akane Onogi Naoki Watanabe Takuji Tanaka Ryogo Aoki;Yoshikazu Ikoma;Asuka Ohashi;Riyoko Niwa;Fumumasa Etori;Masashi Matsuyama;Akane Onogi;Naoki Watanabe;Takuji Tanaka(Departments of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, Gifu, Japan;Departments of Hematology, Gifu Municipal Hospital, Gifu, Japan)

机构地区：[1]Departments of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, Gifu, Japan [2]Departments of Hematology, Gifu Municipal Hospital, Gifu, Japan

出　　处：《Open Journal of Pathology》2021年第4期100-109,共10页病理学期刊（英文）

摘　　要：We experienced a case of small, round-cell malignant neoplasm diagnosed by touch smear cytology and histopathology when an open biopsy was performed in a 50-year-old Japanese woman. She was suspected of having a cervical spine tumor after surgery for cervical spine foraminal stenosis. After consent, the cervical spine tumor histologically diagnosed by an open biopsy was confirmed to be Ewing sarcoma (EWS) by genetic testing. EWS belongs to a group of small, round-cell tumors that are morphologically similar and often difficult to differentiate. After the open biopsy, the present patient received radiotherapy, and her plasma level of Pro-Gastrin-Releasing-Peptide was decreased (217.2 pg/ml before surgery to 30.3 pg/ml;reference value: 0 - 80 pg/ml). We herein report the process for making the final diagnosis by focusing on the intraoperative cytology, histopathology, and immunohistochemical findings. Our diagnosis was validated by karyotyping and a fluorescence <em>in-situ</em> hybridization analysis.We experienced a case of small, round-cell malignant neoplasm diagnosed by touch smear cytology and histopathology when an open biopsy was performed in a 50-year-old Japanese woman. She was suspected of having a cervical spine tumor after surgery for cervical spine foraminal stenosis. After consent, the cervical spine tumor histologically diagnosed by an open biopsy was confirmed to be Ewing sarcoma (EWS) by genetic testing. EWS belongs to a group of small, round-cell tumors that are morphologically similar and often difficult to differentiate. After the open biopsy, the present patient received radiotherapy, and her plasma level of Pro-Gastrin-Releasing-Peptide was decreased (217.2 pg/ml before surgery to 30.3 pg/ml;reference value: 0 - 80 pg/ml). We herein report the process for making the final diagnosis by focusing on the intraoperative cytology, histopathology, and immunohistochemical findings. Our diagnosis was validated by karyotyping and a fluorescence <em>in-situ</em> hybridization analysis.

关 键 词：Ewing’s Sarcoma Small Round-Cell Tumors PROGRP Touch Smear Cytology Intra-Operative Pathological Diagnosis Immunohistochemistry 

分 类 号：R73[医药卫生—肿瘤]