Corticosurrenaloma: About a Pediatric Case  

作　　者：Thierry Mukenge Wa Mukengeshay Fatoumata Binta Balde Zineb Benmassaoud Priscilla Kinsala Othmane Allaoui Abdelhalim Mahmoudi Khalid Khattala Sara Benmilloud Youssef Bouabdallah Thierry Mukenge Wa Mukengeshay;Fatoumata Binta Balde;Zineb Benmassaoud;Priscilla Kinsala;Othmane Allaoui;Abdelhalim Mahmoudi;Khalid Khattala;Sara Benmilloud;Youssef Bouabdallah(Service de Chirurgie Pédiatrique, Centre Hospitalier et Universitaire Hassan II de Fès, Fès, Morocco;Service de Pédiatrie, Unité d’Oncologie, Centre Hospitalier et Universitaire Hassan II de Fès, Fès, Morocco;Faculté de Médecine et de Pharmacie, Université Sidi Mohamed Ben Abdallah de Fès, Fès, Morocco)

机构地区：[1]Service de Chirurgie Pédiatrique, Centre Hospitalier et Universitaire Hassan II de Fès, Fès, Morocco [2]Service de Pédiatrie, Unité d’Oncologie, Centre Hospitalier et Universitaire Hassan II de Fès, Fès, Morocco [3]Faculté de Médecine et de Pharmacie, Université Sidi Mohamed Ben Abdallah de Fès, Fès, Morocco

出　　处：《Open Journal of Pediatrics》2022年第2期449-452,共4页儿科学期刊（英文）

摘　　要：Introduction: This study aims to describe the outcome of adrenocortical cancer in children through observation. Observation: A 10-year-old girl with no previous pathological history. She presented headaches and severe hypertension with clinical and biological signs of hyperandrogenism for 6 months. An abdominal CT scan showed an encapsulated left adrenal mass without local or regional invasion or secondary location. A pheochromocytoma or adrenal neuroblastoma was first suspected. The blood pressure was stable at 130/65 mmHg under antihypertensive drugs. She underwent a complete tumor resection without any intraoperative incident. The pathologic study confirmed the adrenocortical carcinoma scored Weiss 7. The severe high blood pressure reappeared 2-year later despite antihypertensive drugs. The thoracic abdominal and pelvic CT scan showed a locally advanced tumor recurrence in the left adrenal gland with parenchymal nodes in the lungs and liver. The outcome was fatal despite medical and surgical management. Conclusion: Adrenocortical cancer is a rare tumor. It is important to hormonal testing in the presence of Cushing’s syndrome in children. It can give a strong indication of the diagnostic possibilities. Histology confirms the diagnosis. The evolution is covered by complications, in particular recurrence with life-threatening metastases.Introduction: This study aims to describe the outcome of adrenocortical cancer in children through observation. Observation: A 10-year-old girl with no previous pathological history. She presented headaches and severe hypertension with clinical and biological signs of hyperandrogenism for 6 months. An abdominal CT scan showed an encapsulated left adrenal mass without local or regional invasion or secondary location. A pheochromocytoma or adrenal neuroblastoma was first suspected. The blood pressure was stable at 130/65 mmHg under antihypertensive drugs. She underwent a complete tumor resection without any intraoperative incident. The pathologic study confirmed the adrenocortical carcinoma scored Weiss 7. The severe high blood pressure reappeared 2-year later despite antihypertensive drugs. The thoracic abdominal and pelvic CT scan showed a locally advanced tumor recurrence in the left adrenal gland with parenchymal nodes in the lungs and liver. The outcome was fatal despite medical and surgical management. Conclusion: Adrenocortical cancer is a rare tumor. It is important to hormonal testing in the presence of Cushing’s syndrome in children. It can give a strong indication of the diagnostic possibilities. Histology confirms the diagnosis. The evolution is covered by complications, in particular recurrence with life-threatening metastases.

关 键 词：Adrenal Tumor Adrenal Cortex HYPERANDROGENISM CHILD 

分 类 号：R73[医药卫生—肿瘤]