Glomerular Filtration Rate of Children with Sickle Cell Disease Compared to Non-Sickle Cell Patients in Donka Pediatric Emergencies and SOS Drepano-Guinea Center  

作　　者：Mohamed Lamine Diallo Emmanuel Camara Mamadou Moustapha Diop Mamadou Cire Barry Fatoumata Binta Diallo Aissata Barry Saliou Bellanrcisse Diallo Narcisse Idohou Ganin Paul Ulrich N’dri N’gotta Mamdy Dramé Telly Sy Mohamed Lamine Kaba Mohamed Lamine Diallo;Emmanuel Camara;Mamadou Moustapha Diop;Mamadou Cire Barry;Fatoumata Binta Diallo;Aissata Barry;Saliou Bellanrcisse Diallo;Narcisse Idohou;Ganin Paul Ulrich N’dri N’gotta;Mamdy Dramé;Telly Sy;Mohamed Lamine Kaba(Paediatric Emergency, Donka National Hospital, Conakry, Guinea;Paediatrics Department, Donka National Hospital, Conakry, Guinea;Department of Paediatrics, Hô,pital National Ignace Deen, Conakry, Guinea;Centre SOS Drépano-Guinée, Conakry, Guinea;Department of Gynaecology and Obstetrics, Hô,pital National Ignace Deen, Conakry, Guinea;Haemodialysis Department, Donka National Hospital, Conakry, Guinea)

机构地区：[1]Paediatric Emergency, Donka National Hospital, Conakry, Guinea [2]Paediatrics Department, Donka National Hospital, Conakry, Guinea [3]Department of Paediatrics, Hô,pital National Ignace Deen, Conakry, Guinea [4]Centre SOS Drépano-Guinée, Conakry, Guinea [5]Department of Gynaecology and Obstetrics, Hô,pital National Ignace Deen, Conakry, Guinea [6]Haemodialysis Department, Donka National Hospital, Conakry, Guinea

出　　处：《Open Journal of Pediatrics》2023年第4期562-567,共6页儿科学期刊（英文）

摘　　要：Introduction: Our study focused on the evaluation of renal function in children with sickle cell disease compared to children without sickle cell disease at the pediatric emergency unit of the Donka National Hospital and SOS Drepano-Guinea center. Patients and Methods: This was a cross-sectional descriptive and analytical study lasting 3 months (October 1 to December 31, 2020). Were included, all sickle cell and non-sickle cell children aged 0 to 15 received on an outpatient basis and had undergone an exploration of renal function (serum creatinine and urine dipstick). Results: We performed the urine dipstick and serum creatinine in 75 children, 45 of whom were sickle cell and 30 were not sickle cell. 27 of our patients or 36% had a reduction in GFR, among them 9 or 20% were sickle cell and 18 or 60% were not sickle cell. The most affected age group was 5 to 9 years in sickle cell (66.7%) and non-sickle cell (38.9%). In sickle cell patients, 9 cases (100%) had mild renal failure (IRL). Non-sickle cell patients, had 14 cases or 77.8% of IRL and 4 cases (22.2%) of moderate IR. Sickle cell disease and antibiotics which had the respective p-value (0.01);(0.02), were statistically significant with the onset of renal failure. Conclusion: Several factors including sickle cell anemia and antibiotics are believed to be involved in lowering GFR. It would be essential to detect early the children received in consultation.Introduction: Our study focused on the evaluation of renal function in children with sickle cell disease compared to children without sickle cell disease at the pediatric emergency unit of the Donka National Hospital and SOS Drepano-Guinea center. Patients and Methods: This was a cross-sectional descriptive and analytical study lasting 3 months (October 1 to December 31, 2020). Were included, all sickle cell and non-sickle cell children aged 0 to 15 received on an outpatient basis and had undergone an exploration of renal function (serum creatinine and urine dipstick). Results: We performed the urine dipstick and serum creatinine in 75 children, 45 of whom were sickle cell and 30 were not sickle cell. 27 of our patients or 36% had a reduction in GFR, among them 9 or 20% were sickle cell and 18 or 60% were not sickle cell. The most affected age group was 5 to 9 years in sickle cell (66.7%) and non-sickle cell (38.9%). In sickle cell patients, 9 cases (100%) had mild renal failure (IRL). Non-sickle cell patients, had 14 cases or 77.8% of IRL and 4 cases (22.2%) of moderate IR. Sickle cell disease and antibiotics which had the respective p-value (0.01);(0.02), were statistically significant with the onset of renal failure. Conclusion: Several factors including sickle cell anemia and antibiotics are believed to be involved in lowering GFR. It would be essential to detect early the children received in consultation.

关 键 词：Flow FILTRATION Glomerular CHILD Sickle Cell Disease 

分 类 号：R73[医药卫生—肿瘤]