Management of Opioid Use Disorder in Sickle Cell Anaemia amidst Growing Menace in the General Population  

作　　者：Abimbola Aboluwarin Ayobola Ojuawo Oluwatobi Akanbi Lateef Quadri Hannah Elukpo Adebayo Oloko Kolade Ernest Abimbola Aboluwarin;Ayobola Ojuawo;Oluwatobi Akanbi;Lateef Quadri;Hannah Elukpo;Adebayo Oloko;Kolade Ernest(Paediatric Haematology Unit, Department of Paediatrics, University of Ilorin Teaching Hospital, Ilorin, Nigeria;Institute of Medical Research and Training, University of Ilorin, Ilorin, Nigeria)

机构地区：[1]Paediatric Haematology Unit, Department of Paediatrics, University of Ilorin Teaching Hospital, Ilorin, Nigeria [2]Institute of Medical Research and Training, University of Ilorin, Ilorin, Nigeria

出　　处：《Open Journal of Pediatrics》2023年第6期807-820,共14页儿科学期刊（英文）

摘　　要：Nigeria has a very high number of sickle cell disease (SCD) population with addition of 150,000 babies born annually with the disease. Early infant diagnosis and good care make many of these babies survive to adulthood. Severe pain requiring moderately strong or very strong analgesics is a common presentation of patients with Sickle Cell Anaemia. Paediatricians find ready usefulness of Opioids which are very useful for the painful episodes among these patients. Therefore, the chances of abuse and addiction to these medications become very high and constitute additional burden on the deficient manpower in the health sector. Opioid Use Disorder among Sickle Cell Disease patients has subtle presentation, so a high index of suspicion is required to make both the diagnosis and referral to treatment centres. In this review, the epidemiology, pain pathophysiology, behavioural and pharmacologic therapy have been re-examined.Nigeria has a very high number of sickle cell disease (SCD) population with addition of 150,000 babies born annually with the disease. Early infant diagnosis and good care make many of these babies survive to adulthood. Severe pain requiring moderately strong or very strong analgesics is a common presentation of patients with Sickle Cell Anaemia. Paediatricians find ready usefulness of Opioids which are very useful for the painful episodes among these patients. Therefore, the chances of abuse and addiction to these medications become very high and constitute additional burden on the deficient manpower in the health sector. Opioid Use Disorder among Sickle Cell Disease patients has subtle presentation, so a high index of suspicion is required to make both the diagnosis and referral to treatment centres. In this review, the epidemiology, pain pathophysiology, behavioural and pharmacologic therapy have been re-examined.

关 键 词：Sickle Cell Disease Opioid Use Disorder Global Menace Treatment Centres True Addiction and Pseudo-Addiction 

分 类 号：R73[医药卫生—肿瘤]