Incidental Finding of Pyeloureteral Junction Syndrome during Extension Workup for Prostatic Adenocarcinoma  

作　　者：Jean Cedrick Fouda Philip Fernandez Owon’Abessolo Frantz Guy Epoupa Ngalle Junior Barthélémy Mekeme Mekeme Alkadri Diarra Amadou Kassogue Armel Quentin Essomba Ambroise Seme Francis Nwatsock Ngapagna Youssofa Herve Moby Guy Aristide Bang Pierre Ongolo Zogo Pierre Joseph Fouda Angwafo Fru III Jean Cedrick Fouda;Philip Fernandez Owon’Abessolo;Frantz Guy Epoupa Ngalle;Junior Barthélémy Mekeme Mekeme;Alkadri Diarra;Amadou Kassogue;Armel Quentin Essomba;Ambroise Seme;Francis Nwatsock;Ngapagna Youssofa;Herve Moby;Guy Aristide Bang;Pierre Ongolo Zogo;Pierre Joseph Fouda;Angwafo Fru III(Urpology and Andrology Department, Central Hospital of Yaounde, Yaounde, Cameroon;Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon;Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon;Urology Department, Luxembourg University Teaching Hospital of Bamako, Bamako, Mali;Urology Department, Pr Bocar Sidi Sall University Teaching Hospital of Kati, Kati, Mali)

机构地区：[1]Urpology and Andrology Department, Central Hospital of Yaounde, Yaounde, Cameroon [2]Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon [3]Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon [4]Urology Department, Luxembourg University Teaching Hospital of Bamako, Bamako, Mali [5]Urology Department, Pr Bocar Sidi Sall University Teaching Hospital of Kati, Kati, Mali

出　　处：《Open Journal of Urology》2024年第10期532-536,共5页泌尿学期刊（英文）

摘　　要：Introduction: Prostate cancer is one of the most common cancers in men. In cases of suspected locally advanced disease or lymph node or bone metastases, thoraco-abdomino-pelvic CT is still useful for detecting visceral metastases. In the course of this extension work-up, other abnormalities may be discovered by chance, which had previously remained silent, and which could be diagnosed and managed in childhood, hence the interest of presenting a case of incidental finding of pyeloureteral junction syndrome during extension workup for prostatic adenocarcinoma at Yaounde Central Hospital. Observation: A 72-year-old patient presented to the department with acute urinary retention. The clinical examination, with an empty bladder, and in particular the digital rectal exam (DRE), was in favor of malignant prostatic hypertrophy. A workup was ordered, including a total PSA returned to 61.3 ng/ml (PSA performed one week after the episode of acute urinary retention) with cytobacteriological examination of sterile urine. Renal function was slightly impaired, with creatinemia at 14 ng/ml. Renal and vesico-prostatic ultrasound revealed a 57 g prostate with regular, clean contours and a polycystic right kidney. A prostate biopsy was indicated, which revealed a histopathological aspect in favor of a prostatic adenocarcinoma ISUP 1. An extension work-up including a thoraco-abdomino-pelvic CT scan revealed no signs of local or distant secondary localization, but a pyeloureteral junction syndrome with significant hydronephrosis, parenchymal destruction and compensatory hypertrophy of the contralateral kidney was found. Conclusion: The prostate cancer extension work-up revealed a pathology that can be diagnosed early. It is therefore important to reinforce prenatal and natal screening, which will enable malformative uropathies to be identified early and corrected in time to preserve patients’ renal function. Furthermore, we must be careful in the ultrasound diagnosis of pyeloureteral junction syndrome.Introduction: Prostate cancer is one of the most common cancers in men. In cases of suspected locally advanced disease or lymph node or bone metastases, thoraco-abdomino-pelvic CT is still useful for detecting visceral metastases. In the course of this extension work-up, other abnormalities may be discovered by chance, which had previously remained silent, and which could be diagnosed and managed in childhood, hence the interest of presenting a case of incidental finding of pyeloureteral junction syndrome during extension workup for prostatic adenocarcinoma at Yaounde Central Hospital. Observation: A 72-year-old patient presented to the department with acute urinary retention. The clinical examination, with an empty bladder, and in particular the digital rectal exam (DRE), was in favor of malignant prostatic hypertrophy. A workup was ordered, including a total PSA returned to 61.3 ng/ml (PSA performed one week after the episode of acute urinary retention) with cytobacteriological examination of sterile urine. Renal function was slightly impaired, with creatinemia at 14 ng/ml. Renal and vesico-prostatic ultrasound revealed a 57 g prostate with regular, clean contours and a polycystic right kidney. A prostate biopsy was indicated, which revealed a histopathological aspect in favor of a prostatic adenocarcinoma ISUP 1. An extension work-up including a thoraco-abdomino-pelvic CT scan revealed no signs of local or distant secondary localization, but a pyeloureteral junction syndrome with significant hydronephrosis, parenchymal destruction and compensatory hypertrophy of the contralateral kidney was found. Conclusion: The prostate cancer extension work-up revealed a pathology that can be diagnosed early. It is therefore important to reinforce prenatal and natal screening, which will enable malformative uropathies to be identified early and corrected in time to preserve patients’ renal function. Furthermore, we must be careful in the ultrasound diagnosis of pyeloureteral junction syndrome.

关 键 词：Prostate Cancer Pyeloureteral Junction Syndrome Prenatal Diagnosis Morphological Diagnosis 

分 类 号：R73[医药卫生—肿瘤]