Immunohistochemical Evaluation of Vascular Endothelial Growth Factor(VEGF)in Splenic Hemangiomas and Hemangiosarcomas in Dogs  

作　　者：Andressa Gianotti Campos Juliana Alvares Duarte Bonini Campos Daniel Soares Sanches Maria Lucia Zaidan Dagli Julia Maria Matera 

机构地区：[1]Department of Surgery,School of Veterinary Medicine and Animal Science,University of Sao Paulo,Sao Paulo,Brazil [2]Department of Biostatistics and Scientific Method,School of Dentistry,Sao Paulo State University,Araraquara,Brazil [3]Department of Animal Pathology,School of Veterinary Medicine and Animal Science,University of Sao Paulo,Sao Paulo,Brazil

出　　处：《Open Journal of Veterinary Medicine》2012年第4期191-195,共5页兽医学（英文）

摘　　要：Formation of new blood vessels is paramount for tumour growth and metastatic dissemination and vascular endothelial growth factor (VEGF) is one of the key regulators of this process. The purpose of this study was to evaluate the immunohistochemical expression of VEGF in 23 splenic hemangiosarcomas and 7 splenic hemangiomas in dogs. Blood tests performed previous to splenectomy were analysed for correlation with tumour VEGF expression. Results showed significantly higher VEGF expression in hemangiosarcomas than hemangiomas and lower hematocrit values and red cell count in dogs affected with malignant neoplasia (P < 0.05). These findings suggest the presence of high VEGF levels may be related to the malignant vascular proliferation seen in hemangiosarcomas.Formation of new blood vessels is paramount for tumour growth and metastatic dissemination and vascular endothelial growth factor (VEGF) is one of the key regulators of this process. The purpose of this study was to evaluate the immunohistochemical expression of VEGF in 23 splenic hemangiosarcomas and 7 splenic hemangiomas in dogs. Blood tests performed previous to splenectomy were analysed for correlation with tumour VEGF expression. Results showed significantly higher VEGF expression in hemangiosarcomas than hemangiomas and lower hematocrit values and red cell count in dogs affected with malignant neoplasia (P < 0.05). These findings suggest the presence of high VEGF levels may be related to the malignant vascular proliferation seen in hemangiosarcomas.

关 键 词：CANINE SPLEEN Angiogenesis HEMANGIOSARCOMA Immunohistochemistry Vascular Endothelial Growth Factor 

分 类 号：R73[医药卫生—肿瘤]