Toxicity and Viral Load in Urine during Valganciclovir Therapy in Premature Infants  

作　　者：Merel Boesveld Henrica L. M. Van Straaten Marieke A. C. Hemels 

机构地区：[1]Department of Neonatology, Isala, Zwolle, Netherlands

出　　处：《Pharmacology & Pharmacy》2017年第8期275-282,共8页药理与制药（英文）

摘　　要：Cytomegalovirus (CMV) infection is the most important cause of mental retardation and sensorineural hearing loss. Antiviral treatment with valganciclovir, a relatively new but potential toxic oral drug, is recommended to prevent further hearing deterioration. In this retrospective cohort study we evaluated the relation between the dose of valganciclovir and the reduction of CMV viral load, as well as the toxicity. All neonates with gestationalCytomegalovirus (CMV) infection is the most important cause of mental retardation and sensorineural hearing loss. Antiviral treatment with valganciclovir, a relatively new but potential toxic oral drug, is recommended to prevent further hearing deterioration. In this retrospective cohort study we evaluated the relation between the dose of valganciclovir and the reduction of CMV viral load, as well as the toxicity. All neonates with gestational age

关 键 词：CMV PREMATURE INFANTS VALGANCICLOVIR Treatment 

分 类 号：R73[医药卫生—肿瘤]