Acetylation of Starch Extracted from Rejected Fruits of <i>Musa ×paradisiaca L.</i>to Obtain a Pharmaceutical Disintegrant  

作　　者：Karla Dumancela Eduardo Mayorga Javier Santamaría- Aguirre Karla Dumancela;Eduardo Mayorga;Javier Santamaría- Aguirre(Facultad de Ciencias Químicas, Universidad Central del Ecuador, Quito, Ecuador;Instituto de Investigación en Salud Pública y Zoonosis, CIZ, Universidad Central del Ecuador, Quito, Ecuador)

机构地区：[1]Facultad de Ciencias Químicas, Universidad Central del Ecuador, Quito, Ecuador [2]Instituto de Investigación en Salud Pública y Zoonosis, CIZ, Universidad Central del Ecuador, Quito, Ecuador

出　　处：《Pharmacology & Pharmacy》2020年第6期118-126,共9页药理与制药（英文）

摘　　要：There are many natural sources to obtain pharmaceutical grade starch, one of which is banana (<i><i><span style="font-family:Verdana;">Musa</span></i><span style="font-family:Verdana;"> × </span><i><span style="font-family:Verdana;">paradisiaca L</span></i><span style="font-family:Verdana;">.</span></i>);nevertheless, the use of native starch has certain disadvantages compared to modified starches, whose disintegrating properties are better. In this study, starch extracted from rejected fruits of <i><i><span style="font-family:Verdana;">Musa</span></i><span style="font-family:Verdana;"> × </span><i><span style="font-family:Verdana;">paradisiaca L</span></i><span style="font-family:Verdana;">.</span></i>, was modified by acetylation, under the following optimized experimental conditions: 130 mL acetic anhydride, 3 mL sodium hydroxide 50% p/v for each 15 grams of native starch, at 123℃ during 3 hours. The reaction resulted in a modified green banana starch with twice as much swelling capacity compared to unmodified (native) starch;acetylation was verified by infrared spectroscopy and degree of substitution of acetyl groups by back titration. The dissolution profiles of Ibuprofen tablets <span style="font-family:Verdana;">made </span><span style="font-family:Verdana;">with</span><span> </span><span style="font-family:Verdana;">banana modified starch and commercial disintegrant, ha</span><span style="font-family:Verdana;">ve</span><span style="font-family:Verdana;"> no differences according with their similarity factor</span><span style="font-family:Verdana;">,</span><span style="font-family:;" "=""> <i><span style="font-family:Verdana;">f</span></i>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;">. It is concluded that it is feasible to use green banana starch modified through acetylation as a pharmaceutical disintegrant.</span></span>There are many natural sources to obtain pharmaceutical grade starch, one of which is banana (<i><i><span style="font-family:Verdana;">Musa</span></i><span style="font-family:Verdana;"> × </span><i><span style="font-family:Verdana;">paradisiaca L</span></i><span style="font-family:Verdana;">.</span></i>);nevertheless, the use of native starch has certain disadvantages compared to modified starches, whose disintegrating properties are better. In this study, starch extracted from rejected fruits of <i><i><span style="font-family:Verdana;">Musa</span></i><span style="font-family:Verdana;"> × </span><i><span style="font-family:Verdana;">paradisiaca L</span></i><span style="font-family:Verdana;">.</span></i>, was modified by acetylation, under the following optimized experimental conditions: 130 mL acetic anhydride, 3 mL sodium hydroxide 50% p/v for each 15 grams of native starch, at 123℃ during 3 hours. The reaction resulted in a modified green banana starch with twice as much swelling capacity compared to unmodified (native) starch;acetylation was verified by infrared spectroscopy and degree of substitution of acetyl groups by back titration. The dissolution profiles of Ibuprofen tablets <span style="font-family:Verdana;">made </span><span style="font-family:Verdana;">with</span><span> </span><span style="font-family:Verdana;">banana modified starch and commercial disintegrant, ha</span><span style="font-family:Verdana;">ve</span><span style="font-family:Verdana;"> no differences according with their similarity factor</span><span style="font-family:Verdana;">,</span><span style="font-family:;" "=""> <i><span style="font-family:Verdana;">f</span></i>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;">. It is concluded that it is feasible to use green banana starch modified through acetylation as a pharmaceutical disintegrant.</span></span>

关 键 词：Modified Banana Starch ACETYLATION Swelling Capacity DISINTEGRANT Dissolution Profile 

分 类 号：O17[理学—数学]