Ischemic Conditioning-Mediated Myocardial Protection in Relation to Duration of Coronary Occlusion  

作　　者：John G. Kingma Jr. John G. Kingma Jr.(Department of Medicine, Faculty of Medicine, Pavillon Ferdinand-Vandry, Université Laval, Québec, Canada)

机构地区：[1]Department of Medicine, Faculty of Medicine, Pavillon Ferdinand-Vandry, Université Laval, Québec, Canada

出　　处：《World Journal of Cardiovascular Diseases》2021年第3期210-222,共13页心血管病（英文）

摘　　要：<strong>Background</strong><span style="font-family:Verdana;"><b>:</b></span><span style="font-family:Verdana;"> Myocardial ischemia is a dynamic process whereby a cascade of events is initiated to stimulate transition from reversible to irreversible cellular injury. Non-pharmacologic approaches to cellular protection, such as ische</span><span style="font-family:;" "=""><span style="font-family:Verdana;">mic conditioning, delay onset of cellular injury in most organs in a host of animal species;however the degree of protection is limited to rather short durations of ischemia. In the present study, we examined whether protection afforded by ischemic conditioning could be extended beyond currently established limits of coronary occlusion in an </span><i><span style="font-family:Verdana;">in situ</span></i><span style="font-family:Verdana;"> animal model.</span></span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;"><b>Methods</b></span><span style="font-family:Verdana;"><b>:</b></span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">Rabbits (n</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">=</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">106) were exposed to 30-, 60-, 120-, 180-, 240-, or 360-min coronary</span><span style="font-family:Verdana;"> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">occlusion followed by 180-min coronary reperfusion (</span><i><span style="font-family:Verdana;">i</span></i><span style="font-family:Verdana;">.</span><i><span style="font-family:Verdana;">e</span></i><span style="font-family:Verdana;">. non-conditioned</span></span><span style="font-family:;" "=""><span style="font-family:Verdana;"> control groups). Ischemic conditioned rabbits were pre-treated by ischemic conditioning (</span><i><span style="font-family:Verdana;">i</span></i><span style="font-family:Verdana;">.</span><i><span style="font-family:Verdana;">e</span><strong>Background</strong><span style="font-family:Verdana;"><b>:</b></span><span style="font-family:Verdana;"> Myocardial ischemia is a dynamic process whereby a cascade of events is initiated to stimulate transition from reversible to irreversible cellular injury. Non-pharmacologic approaches to cellular protection, such as ische</span><span style="font-family:;" "=""><span style="font-family:Verdana;">mic conditioning, delay onset of cellular injury in most organs in a host of animal species;however the degree of protection is limited to rather short durations of ischemia. In the present study, we examined whether protection afforded by ischemic conditioning could be extended beyond currently established limits of coronary occlusion in an </span><i><span style="font-family:Verdana;">in situ</span></i><span style="font-family:Verdana;"> animal model.</span></span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;"><b>Methods</b></span><span style="font-family:Verdana;"><b>:</b></span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">Rabbits (n</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">=</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">106) were exposed to 30-, 60-, 120-, 180-, 240-, or 360-min coronary</span><span style="font-family:Verdana;"> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">occlusion followed by 180-min coronary reperfusion (</span><i><span style="font-family:Verdana;">i</span></i><span style="font-family:Verdana;">.</span><i><span style="font-family:Verdana;">e</span></i><span style="font-family:Verdana;">. non-conditioned</span></span><span style="font-family:;" "=""><span style="font-family:Verdana;"> control groups). Ischemic conditioned rabbits were pre-treated by ischemic conditioning (</span><i><span style="font-family:Verdana;">i</span></i><span style="font-family:Verdana;">.</span><i><span style="font-family:Verdana;">e</span>

关 键 词：ISCHEMIA REPERFUSION Infarct Size Biomarkers Ischemic Conditioning Rab-bits 

分 类 号：R54[医药卫生—心血管疾病]