Vitamin E in ataxia and neurodegenerative diseases:A review  

作　　者：Fatima Imounan Naima Bouslam Jehanne Aasfara Kaoutar El Alaoui Wafa Regragui El Hachmia Ait Benhaddou Ahmed Bouhouche Ali Benomar Mohamed Yahyaoui 

机构地区：[1]Mohammed V Souissi University,CHU Ibn Sina,Neurology B and Neurogenetics Department,Hopital des Specialites,Rabat,Morocco [2]Mohammed V Souissi University,Faculte de Medecine et de Pharmacie Rabat,Centre de Recherche en Epidemiologie Clinique et Essais Therapeutiques(CRECET),Rabat,Morocco

出　　处：《World Journal of Neuroscience》2012年第4期217-222,共6页神经科学国际期刊（英文）

摘　　要：Vitamin E is one of the most important lipid-soluble antioxidants. It is essential for the neurological function but its role in the central nervous system has not fully been elucidated. It is known that tocopherol acts in protecting cell membranes from oxidative damage and it can act as an anti-in?ammatory agent, which may also be neuroprotective, as well as regulating speci?c enzymes. There is growing evidence that oxidative stress plays a key role in the pathophysiology of several neurodegenerative disorders. These diseases are defined by the progressive loss of speci?c neuronal cell populations and are associated with protein aggregates. We reviewed some aspects related to the role of antioxidant properties of Vitamin E in preventing and/or curing neurodegenerative disorders such as the Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, ataxia, tardive dyskinesia and Huntington’s disease.Vitamin E is one of the most important lipid-soluble antioxidants. It is essential for the neurological function but its role in the central nervous system has not fully been elucidated. It is known that tocopherol acts in protecting cell membranes from oxidative damage and it can act as an anti-in?ammatory agent, which may also be neuroprotective, as well as regulating speci?c enzymes. There is growing evidence that oxidative stress plays a key role in the pathophysiology of several neurodegenerative disorders. These diseases are defined by the progressive loss of speci?c neuronal cell populations and are associated with protein aggregates. We reviewed some aspects related to the role of antioxidant properties of Vitamin E in preventing and/or curing neurodegenerative disorders such as the Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, ataxia, tardive dyskinesia and Huntington’s disease.

关 键 词：Vitamin E Neurodegenerative Diseases Ataxia with Vitamin E Deficiency 

分 类 号：R73[医药卫生—肿瘤]