Homeostatic Conductance and Parasympathetic Basis Alteration: Two Alternative Approaches to Deep Brain Stimulation in Parkinson’s, Obsessive Compulsive Disorder and Depression  

作　　者：Richard Lawrence Norman Richard Lawrence Norman(Editorial Department, Journal of Unconscious Psychology and Mind Magazine, O’Brien, USA)

机构地区：[1]Editorial Department, Journal of Unconscious Psychology and Mind Magazine, O’Brien, USA

出　　处：《World Journal of Neuroscience》2016年第1期52-61,共10页神经科学国际期刊（英文）

摘　　要：Derived through the dual focus of psychology and neuroscience, disciplines such as Affective Neuroscience and Neuropsychoanalysis may offer new directions of approach to many pathologies, which demonstrate psychical and somatic etiology. Insights gained from these two trustworthy yet still peripheral scientific disciplines, are deserving of consideration and exploration. It is the purpose of this paper to offer up several such possible new avenues of exploration, as they relate to depression, Obsessive Compulsive Disorder (OCD), and Parkinson’s Disease (PD). The basic therapeutic focus in deriving these proposed new clinical approaches is twofold: 1) Deep Brain Stimulation (DBS) and 2) Mnemic alteration via neuropeptide assisted therapy producing positive relative adjustment in the balance of basic sympathetic (dopaminergic) and parasympathetic affective circuitry independent of drugs or surgery. New conductance level and target strategies designed to prevent homeostatic degeneration are advanced under the concept of homeostatic conductance. New electrical stimulation targets are suggested, which restore basic rhythmic balance between pathologically affected and unaffected brain areas. In this way, we offer up new directions for research, strategies for noninvasive and nontoxic potential therapies and new targets/ approaches to DBS therapy.Derived through the dual focus of psychology and neuroscience, disciplines such as Affective Neuroscience and Neuropsychoanalysis may offer new directions of approach to many pathologies, which demonstrate psychical and somatic etiology. Insights gained from these two trustworthy yet still peripheral scientific disciplines, are deserving of consideration and exploration. It is the purpose of this paper to offer up several such possible new avenues of exploration, as they relate to depression, Obsessive Compulsive Disorder (OCD), and Parkinson’s Disease (PD). The basic therapeutic focus in deriving these proposed new clinical approaches is twofold: 1) Deep Brain Stimulation (DBS) and 2) Mnemic alteration via neuropeptide assisted therapy producing positive relative adjustment in the balance of basic sympathetic (dopaminergic) and parasympathetic affective circuitry independent of drugs or surgery. New conductance level and target strategies designed to prevent homeostatic degeneration are advanced under the concept of homeostatic conductance. New electrical stimulation targets are suggested, which restore basic rhythmic balance between pathologically affected and unaffected brain areas. In this way, we offer up new directions for research, strategies for noninvasive and nontoxic potential therapies and new targets/ approaches to DBS therapy.

关 键 词：Deep-Brain-Stimulation Obsessive-Compulsive-Disorder DEPRESSION Parkinson’s Hippocampus 

分 类 号：R74[医药卫生—神经病学与精神病学]