Case Report: A 72 Years Old Man with Isaacs’ Syndrome: A Rare Entity with Different Outcomes  

作　　者：Akam A. Saeed Zana A. Mohammed Rebeen R. Saeed Akam A. Saeed;Zana A. Mohammed;Rebeen R. Saeed(Shar Teaching Hospital of Sulaimania, Sulaimania, Iraq;General University Teaching Hospital of Sulaimania, Sulaimania, Iraq;School of Medicine, University of Sulaimania, Sulaimania, Iraq)

机构地区：[1]Shar Teaching Hospital of Sulaimania, Sulaimania, Iraq [2]General University Teaching Hospital of Sulaimania, Sulaimania, Iraq [3]School of Medicine, University of Sulaimania, Sulaimania, Iraq

出　　处：《World Journal of Neuroscience》2016年第2期82-84,共3页神经科学国际期刊（英文）

摘　　要：Neuromyotonia is a neuromuscular hyperexitability disorder characterized by muscle stiffness caused by continuous muscle fiber activity. It is an immune mediated disorder with elevated antibody level against presynaptic, voltage gated potassium channels, either as isolation or as a paraneoplastic process. Symptoms usually include muscle twitching during rest (myokymia), cramps, peudomyotonia (delayed relaxation), increased sweating, and sometimes motor weakness. In this case report, we present a seventy-two years old man who presented with pain in both thighs for one month. It gradually became worse to involve feet and chest. His brain CT scan showed features of brain atrophy. EMG showed fasciculation along neuromyotonic discharges with characteristic wave in frequency and amplitude typical of Isaacs’ syndrome. Potassium channel antibodies were very high. Diagnosis of Isaacs’ syndrome was made. He was followed up for two months with treatment by three-day course of methyl prednisolone followed by oral steroid and methotrexate with much improvement. This is the first case of Isaacs’ syndrome in Kurdistan.Neuromyotonia is a neuromuscular hyperexitability disorder characterized by muscle stiffness caused by continuous muscle fiber activity. It is an immune mediated disorder with elevated antibody level against presynaptic, voltage gated potassium channels, either as isolation or as a paraneoplastic process. Symptoms usually include muscle twitching during rest (myokymia), cramps, peudomyotonia (delayed relaxation), increased sweating, and sometimes motor weakness. In this case report, we present a seventy-two years old man who presented with pain in both thighs for one month. It gradually became worse to involve feet and chest. His brain CT scan showed features of brain atrophy. EMG showed fasciculation along neuromyotonic discharges with characteristic wave in frequency and amplitude typical of Isaacs’ syndrome. Potassium channel antibodies were very high. Diagnosis of Isaacs’ syndrome was made. He was followed up for two months with treatment by three-day course of methyl prednisolone followed by oral steroid and methotrexate with much improvement. This is the first case of Isaacs’ syndrome in Kurdistan.

关 键 词：Issacs Syndrome Myokymia NEUROMYOTONIA NEUROLOGY Motor DISORDERS HYPEREXCITABILITY 

分 类 号：O15[理学—数学]