HYPEREXCITABILITY

作品数：18被引量：34H指数：3
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相关领域：医药卫生更多>>
相关期刊：《World Journal of Cardiology》《Signal Transduction and Targeted Therapy》《Neuroimmunology and Neuroinflammation》《Translational Neurodegeneration》更多>>
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The Contributions of Thrombospondin-1 to Epilepsy Formation被引量：1
《Neuroscience Bulletin》2024年第5期658-672,共15页Yao Cheng Yujie Zhai Yi Yuan Qiaoyun Wang Shucui Li Hongliu Sun 
supported by the Natural Science Foundation of Shandong Province(ZR2021MH034 and ZR2022MH059);the National Natural Science Foundation of China(81573412).We’d like to thank Editage for English language editing.
Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability induced by an imbalance between excitatory and inhibitory networks.Abnormal synaptogenesis plays a vital role in the formation of...
关键词：Thrombospondin-1 EPILEPTOGENESIS SYNAPTOGENESIS HYPEREXCITABILITY 
Hypocretin neuron hyperexcitability in the hypothalamus:a newly discovered culprit in aging-related sleep impairment被引量：1
《Signal Transduction and Targeted Therapy》2022年第8期2648-2649,共2页Tianbai Li Congcong Jia Weidong Le 
supported by the National Natural Science Foundation of China(NSFC 82001483 and 82101560).
The recent research published in Science by Li et al.1 provides compelling evidence that the hyperexcitability of arousalpromoting hypocretin(Hcrt,also called orexin)neurons is closely associated with sleep instabilit...
关键词：SLEEP IMPAIRMENT al. 
EEG/ERP evidence of possible hyperexcitability in older adults with elevated beta-amyloid
《Translational Neurodegeneration》2022年第1期835-844,共10页Hannes Devos Kathleen Gustafson Ke Liao Pedram Ahmadnezhad Bradley Estes Laura E.Martin Jonathan D.Mahnken William M.Brooks Jeffrey M.Burns 
the National Institute on Aging of the National Institutes of Health under Award Number K01 AG058785;This study was supported in part by a pilot grant of the KU Alzheimer Disease Center(P30 AG035982).
Background: Although growing evidence links beta-amyloid (Aβ) and neuronal hyperexcitability in preclinical mouse models of Alzheimer’s disease (AD), a similar association in humans is yet to be established. The fir...
关键词：Event-related potentials Electro-encephalography Working memory Older adults PRECLINICAL BETA-AMYLOID 
D2 receptor activation relieves pain hypersensitivity by inhibiting superficial dorsal horn neurons in parkinsonian mice被引量：4
《Acta Pharmacologica Sinica》2021年第2期189-198,共10页Dong-liang Tang Yi-wen Luan Chun-yi Zhou Cheng Xiao 
supported by the National Natural Science Foundation of China(81701100(CYZ),81870891(CX),81971038(CYZ));the Fund for Jiangsu Province Specially Appointed Professor(CX,CYZ);the Natural Science Foundation of Jiangsu Province(BK20171160,CYZ);The Natural Science Foundation of the Jiangsu Higher Education Institutions of China(17KJA320007(CX),18KJA320009(CYZ));the Jiangsu Province Fund for Dominant Discipline(Anesthesiology);Startup Funds from Xuzhou Medical University(D2017009,D2017010).
Chronic pain is a common and undertreated nonmotor symptom in Parkinson’s disease(PD).Although chronic pain is improved by L-dopa in some PD patients,the underlying mechanisms remain unclear.In this study,we establis...
关键词：Parkinson’s disease pain hypersensitivity spinal cord dorsal horn neuron HYPEREXCITABILITY dopamine D2 receptor intrathecal administration whole-cell recording 
Deficiency of anti-inflammatory cytokine IL-4 leads to neural hyperexcitability and aggravates cerebral ischemia-reperfusion injury被引量：6
《Acta Pharmaceutica Sinica B》2020年第9期1634-1645,1802,共13页Xiaoling Chen Jingliang Zhang Yan Song Pan Yang Yang Yang Zhuo Huang Kewei Wang 
supported by research grants from the National Natural Science Foundation of China(81573410);the National Science and Technology Major Project(2018ZX09711001-004006,China);the Natural Sciences Foundation of Shandong Province(ZR2015QL008,China)awarded to Kewei Wang
Systematic administration of anti-inflammatory cytokine interleukin 4(IL-4)has been shown to improve recovery after cerebral ischemic stroke.However,whether IL-4 affects neuronal excitability and how IL-4 improves isc...
关键词：Anoxic depolarization IL-4 Ischemia-reperfusion injury Neuronal excitability Synaptic transmissions 
Incidental discovery of right ventricular lipoma in a young female associated with ventricular hyperexcitability: An imaging multimodality approach
《World Journal of Cardiology》2020年第5期220-227,共8页Khaled Elenizi Anthony Matta Rasha Alharthi Francisco Campelo-Parada Thibault Lhermusier Frederic Bouisset Meyer Elbaz Didier Carrié Jerome Roncalli 
BACKGROUND Cardiac lipomas are rare benign tumors commonly found in the right atrium or left ventricle.Patients are usually asymptomatic,and clinical presentation depends on location and adjacent structures impairment...
关键词：Cardiac lipoma Polymorphic premature ventricular contractions Giant cardiac tumor Cardiac magnetic resonance imaging Case report 
Cortical stimulation for treatment of neurological disorders of hyperexcitability: a role of homeostatic plasticity被引量：2
《Neural Regeneration Research》2019年第1期34-38,共5页Zhi Chai Cungen Ma Xiaoming Jin 
supported in part by the NIH DA039530(to XJ);a grant from the CURE Epilepsy Foundation(to XJ)
Hyperexcitability of neural network is a key neurophysiological mechanism in several neurological disorders including epilepsy, neuropathic pain, and tinnitus. Although standard paradigm of pharmacological management ...
关键词：homeostatic plasticity EPILEPSY neuropathic pain cerebral cortex HYPEREXCITABILITY brain injury TINNITUS cortical stimulation 
Prediction of post-progression survival in patientswith advanced hepatocellular carcinoma treated with sorafenib by using time-dependent changes inclinical characteristics
《Hepatoma Research》2018年第3期1-8,共8页Yoshiyuki Wada Yuko Takami Hajime Matsushima Masaki Tateishi Tomoki Ryu Munehiro Yoshitomi Hideki Saitsu 
Aim: Sorafenib has been shown to improve time to tumor progression (TTP) and overall survival (OS) in patients with hepatocellular carcinoma (HCC);however, post-progression survival (PPS) has not been well characteriz...
关键词：Contactin-associated protein-2 ISAAC NEUROMUSCULAR HYPEREXCITABILITY NEUROMYOTONIA VOLTAGE-GATED potassium channel 
Steroids and plasma exchange in Isaacs' syndromewith anti-Caspr2 antibodies
《Neuroimmunology and Neuroinflammation》2018年第3期5-9,共5页Daniele Orsucci Gianfranco Cafforio Gianluca Moscato Alessandro Napolitano Marco Margelli Monica Mazzoni 
Isaacs' syndrome is a disease characterized by nerve hyperexcitability. The patients are commonly treated with symptomatic therapies and immunomodulatory approaches, but no clinical trials are available to date. Here,...
关键词：Contactin-associated protein-2 ISAAC NEUROMUSCULAR HYPEREXCITABILITY NEUROMYOTONIA VOLTAGE-GATED potassium channel 
Inflammatory Changes in Paravertebral Sympathetic Ganglia in Two Rat Pain Models被引量：9
《Neuroscience Bulletin》2018年第1期85-97,共13页Ai-Ling Li Jing-Dong Zhang Wenrui Xie Judith A. Strong Jun-Ming Zhang 
supported in part by National Institutes of Health Grants NS045594,NS055860,and AR068989 to J.M.Z.
Injury to peripheral nerves can lead to neuropathic pain, along with well-studied effects on sensory neurons, including hyperexcitability, abnormal spontaneous activity, and neuroinflammation in the sensory ganglia. N...
关键词：Neuropathic pain SYMPATHETIC Macrophage T cell Satellite glia Inflammation HYPEREXCITABILITY 
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