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Inhibition of the microglial voltage-gated proton channel 1 channel ameliorates diabetes-associated cognitive dysfunction by regulating axon demyelination: 《World Journal of Psychiatry》2025年第3期288-301,共14页Chun-Yu Li Shu-Jun Zhang Jia-Lu Xu Yan Yang Zhi-Xuan Zeng De-Lin Ma; Supported by the National Natural Science Foundation of China,No.82300894.; BACKGROUND Diabetes is associated with increased cognitive decline and dementia due to the loss of myelinated nerve fiber function,which is linked to oligodendrocyte dysfunction.The voltage-gated proton channel 1(Hv1)...; 关键词：Diabetes Cognitive dysfunction Voltage-gated proton channel 1 Neuroinflammation Myelin regeneration

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons: 《Neural Regeneration Research》2025年第2期548-556,共9页Zhihui Ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng Li Jiangtao Sheng; supported by the Natural Science Foundation of Guangdong Province,Nos.2019A1515010649(to WC),2022A1515012044(to JS);the China Postdoctoral Science Foundation,No.2018M633091(to JS).; Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may de...; 关键词：central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

Repressing iron overload ameliorates central poststroke pain via the Hdac2-Kv1.2 axis in a rat model of hemorrhagic stroke被引量：1: 《Neural Regeneration Research》2024年第12期2708-2722,共15页He Fang Mengjie Li Jingchen Yang Shunping Ma Li Zhang Hongqi Yang Qiongyan Tang Jing Cao Weimin Yang; supported by the National Natural Science Foundation of China,Nos.U2004106 (to WY),81971061 (to JC);the Key Scientific Research Project of Colleges and Universities in Henan Province,No.21A320039 (to WY)。; Thalamic hemorrhage can lead to the development of central post-stroke pain.Changes in histone acetylation levels,which are regulated by histone deacetylases,affect the excitability of neurons surrounding the hemorrha...; 关键词：central post-stroke pain hemorrhagic stroke histone deacetylase iron overload voltage-gated potassium ion channel 1.2

Potassium voltage-gated channel subfamily H member 2(KCNH2)is a promising target for incretin secretagogue therapies: 《Signal Transduction and Targeted Therapy》2024年第9期4079-4090,共12页Ying-Chao Yuan Hao Wang Ze-Ju Jiang Chang Liu Qi Li Si-Rui Zhou Jin-Kui Yang; supported by grants from the National Natural Science Foundation of China(81930019)to Jin-Kui Yang;supported by grants from Beijing Municipal Natural Science Foundation(7232232)to Hao Wang。; Derived from enteroendocrine cells(EECs),glucagon-like peptide-1(GLP-1)and glucose-dependent insulinotropic peptide(GIP)are pivotal incretin hormones crucial for blood glucose regulation.Medications of GLP-1 analogs a...; 关键词：KCNH2 POTASSIUM elevated

KCNH2 regulates the growth and metastasis of pancreatic cancer: 《Journal of Pancreatology》2023年第3期101-109,共9页Jinghao Lei Qiang Wang Tengfei Qu Lichao Cha Hanxiang Zhan Jianwei Xu Shanglong Liu Lantian Tian Chuandong Sun Jingyu Cao Fabo Qiu Weidong Guo Bin Zhou; supported by the China Postdoctoral Science Foundation Funded Project(Project No.:2019M662304).; Objective:Due to the characteristics of insidious onset and early metastasis of pancreatic cancer(PC),patients are often diag-nosed at an advanced stage and often delayed in completing surgical resection timely,result...; 关键词：Epithelial-mesenchymal transition METASTASIS Pancreatic cancer Potassium voltage-gated channel subfamily H member 2(KCNH2) Proliferation

Role of the Voltage-Gated Proton Channel Hv1 in Nervous Systems被引量：1: 《Neuroscience Bulletin》2023年第7期1157-1172,共16页Yu Shen Yuncheng Luo Ping Liao Yunxia Zuo Ruotian Jiang; supported by the National Natural Science Foundation of China(32071003,82271249,and 81873808);the 1-3-5 Project for Disciplines of Excellence of West China Hospital of Sichuan University(ZYJC21034).; Hv1 is the only voltage-gated proton-selective channel in mammalian cells.It contains a conserved voltage-sensor domain,shared by a large class of voltage-gated ion channels,but lacks a pore domain.Its primary role is...; 关键词：Voltage-gated ion channel Hv1 PROTON ROS NEUROINFLAMMATION Neurological diseases PAIN

Microglial voltage-gated proton channel Hv1 in spinal cord injury被引量：4: 《Neural Regeneration Research》2022年第6期1183-1189,共7页Jiaying Zheng Madhuvika Murugan Lingxiao Wang Long-Jun Wu; the National Institutes of Health(Nos.R01NS110949,R01NS088627,R01NS112144,R01NS110825,R21AG064159)to LJW.; After spinal cord injury,microglia as the first responders to the lesion display both beneficial and detrimental characteristics.Activated microglia phagocyte and eliminate cell debris,release cytokines to recruit per...; 关键词：Hv1 proton channel ion channels MICROGLIA NADPH oxidase pH regulation reactive oxygen species spinal cord injury

More severe toxicity of gold nanoparticles with rougher surface in mouse hippocampal neurons: 《Journal of Central South University》2021年第12期3642-3653,共12页LIN Xin HU Yan-ling ZHANG Chi YIN Jie CUI Rong YANG Dong-liang CHEN Bo; Project(LY19C090004)supported by the Natural Science Foundation of Zhejiang Province,China;Projects(BK20200710,BK2018077)supported by the Natural Science Foundation of Jiangsu Province,China;Project(NHKY-2019-19)supported by the Nanjing Polytechnic Institute Start Fund,China;Project(202012920026Y)supported by the Innovation and Entrepreneurship Training Program of Jiangsu Province College Students,China。; Gold nanoparticles(GNPs)have been extensively used in nanomedicine and neuroscience owing to their biological inertness,peculiar opto-electronic and physico-chemical features.However,the effect of GNPs shape on the ne...; 关键词：gold nanoparticles action potential voltage-gated sodium current HIPPOCAMPUS patch clamp

Solution structure of the voltage-gated Tim23 channel in complex with a mitochondrial presequence peptide: 《Cell Research》2021年第7期821-824,共4页Shu Zhou Maosen Ruan Yunyan Li Jing Yang Suwen Bai Christian Richter Harald Schwalbe Can Xie Bing Shen Junfeng Wang; supported by the High Magnetic Field Laboratory of Anhui Province;This study was supported by grants from the Ministry of Science and Technology of China(Grant No.,2016YFA0400901);the National Natural Science Foundation of China(Grant No.,U1632274);Hefei Science Center of Chinese Academy of Sciences(Grant No.,2020HSC-CIP011);by iNEXT-Discovery,project number 871037,funded by the Horizon 2020 program of the European Commission.; Dear Editor,Most mitochondrial proteins are synthesized in the cytosol and transported into various mitochondrial subcompartments in a process that is mediated by intricate multimeric machineries.Tim23,the key compone...; 关键词：SEQUENCE CONDUCTING structure

Argemone mexicana extract alleviates gastrointestinal disorders by stimulating muscarinic receptors and blocking voltage-gated L-type calcium channels: 《Asian Pacific Journal of Tropical Biomedicine》2021年第5期214-221,共8页Rabia Iqbal Irfan Hamid Khalid Hussain Janbaz Muhammad Furqan Akhtar Ammara Saleem Ali Sharif Sohaib Peerzada Bushra Akhtar Kashif Sohail Sajid Ali; Objective:To investigate the pharmacological potential of Argemone mexicana in treating constipation and emesis by using in vitro and in vivo models.Methods:The spasmogenic and spasmolytic effects were evaluated on is...; 关键词：Argemone mexicana Muscarinic agonist Calcium channel blocker CONSTIPATION EMESIS

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