The Contributions of Thrombospondin-1 to Epilepsy Formation  

作　　者：Yao Cheng Yujie Zhai Yi Yuan Qiaoyun Wang Shucui Li Hongliu Sun 

机构地区：[1]School of Pharmaceutical Sciences,Binzhou Medical University,Yantai,264003,China

出　　处：《Neuroscience Bulletin》2024年第5期658-672,共15页神经科学通报（英文版）

基　　金：supported by the Natural Science Foundation of Shandong Province(ZR2021MH034 and ZR2022MH059);the National Natural Science Foundation of China(81573412).We’d like to thank Editage for English language editing.

摘　　要：Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability induced by an imbalance between excitatory and inhibitory networks.Abnormal synaptogenesis plays a vital role in the formation of overexcited networks.Recent evidence has confirmed that thrombospondin-1(TSP-1),mainly secreted by astrocytes,is a critical cytokine that regulates synaptogenesis during epileptogenesis.Furthermore,numerous studies have reported that TSP-1 is also involved in other processes,such as angiogenesis,neuroinflammation,and regulation of Ca^(2+)homeostasis,which are closely associated with the occurrence and development of epilepsy.In this review,we summarize the potential contributions of TSP-1 to epilepsy development.

关 键 词：Thrombospondin-1 EPILEPTOGENESIS SYNAPTOGENESIS HYPEREXCITABILITY 

分 类 号：R742.1[医药卫生—神经病学与精神病学]