Mathematical Modeling of Cardiomyocytes’ and Skeletal Muscle Fibers’ Membrane: Interaction with External Mechanical Field  

作　　者：Irina V. Ogneva Nikolay S. Biryukov 

机构地区：[1]Department of Molecular Biomedicine, State Scientific Center of Russian Federation, Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia

出　　处：《Applied Mathematics》2013年第8期1-6,共6页应用数学（英文）

摘　　要：We propose a mathematic model of muscle cell membrane based on thin-walled elastic rod theory. A deformation occurs in rodents’ skeletal and cardiac cells during a period of antiorthostatic suspension. We carried out a quantitative evaluation of the deformation using this model. The calculations showed the deformation in cardiac cells to be greater than in skeletal ones. This data corresponds to experimental results of cell response that appears intense in cardiomyocytes than in skeletal muscle cells. Moreover, the deformation in skeletal and heart muscle cells has a different direction (stretching vs. compression), corresponding to experimental data of different adaptive response generation pathways in cells because of external mechanical condition changes.We propose a mathematic model of muscle cell membrane based on thin-walled elastic rod theory. A deformation occurs in rodents’ skeletal and cardiac cells during a period of antiorthostatic suspension. We carried out a quantitative evaluation of the deformation using this model. The calculations showed the deformation in cardiac cells to be greater than in skeletal ones. This data corresponds to experimental results of cell response that appears intense in cardiomyocytes than in skeletal muscle cells. Moreover, the deformation in skeletal and heart muscle cells has a different direction (stretching vs. compression), corresponding to experimental data of different adaptive response generation pathways in cells because of external mechanical condition changes.

关 键 词：MATHEMATICAL Modeling in BIOLOGY Muscle CELL CELL MECHANOSENSITIVITY MICROGRAVITY 

分 类 号：R73[医药卫生—肿瘤]