In Vitro Evaluation of the Physicochemical Compatibility of Four Perfusion Mixtures: Case of an Ampoule of Paluject® in Glucose Serum with/or without Vogalene®  

作　　者：Alphonse Rodrigue Djiboune Papa Mady Sy Abdou Faye Mamadou Soumboundou Sidy Mouhamed Dieng Mariama Dianké Diédhiou Louis Augustin Diaga Diouf Gora Mbaye Mounibé Diarra Alphonse Rodrigue Djiboune;Papa Mady Sy;Abdou Faye;Mamadou Soumboundou;Sidy Mouhamed Dieng;Mariama Dianké Diédhiou;Louis Augustin Diaga Diouf;Gora Mbaye;Mounibé Diarra(Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal;Biophysics Laboratory, Healthy UFR of Thies, University of Thies, Thies, Senegal;Galenic and Industrial Pharmacy Laboratory, Healthy UFR of Thies, University of Thies, Thies, Senegal)

机构地区：[1]Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal [2]Biophysics Laboratory, Healthy UFR of Thies, University of Thies, Thies, Senegal [3]Galenic and Industrial Pharmacy Laboratory, Healthy UFR of Thies, University of Thies, Thies, Senegal

出　　处：《Journal of Modern Physics》2024年第13期2398-2406,共9页现代物理(英文)

摘　　要：In this study, the physicochemical compatibility and stability of four drug mixtures were evaluated, and the common drug mixtures used in the treatment of severe malaria in children were simulated by gravity perfusion dynamic simulation experiment. The results showed that under experimental conditions, all drug mixtures exhibited clear transparency, stable density and refractive index, and pH values changed by no more than one unit, demonstrating compatibility and stability during the study period.In this study, the physicochemical compatibility and stability of four drug mixtures were evaluated, and the common drug mixtures used in the treatment of severe malaria in children were simulated by gravity perfusion dynamic simulation experiment. The results showed that under experimental conditions, all drug mixtures exhibited clear transparency, stable density and refractive index, and pH values changed by no more than one unit, demonstrating compatibility and stability during the study period.

关 键 词：Physicochemical Compatibility and Stability PERFUSION Paluject® Glucose Serum Vogalene® 

分 类 号：G63[文化科学—教育学]