Pulsed Modulation in Electro-Hyperthermia  

作　　者：Janos Szucs Lajos Konyha Gabor Kertesz Andras Szasz Janos Szucs;Lajos Konyha;Gabor Kertesz;Andras Szasz(Oncotherm Kft., Budars, Hungary;Department of Biotechnics, Hungarian University of Agriculture and Life Sciences, Gdll, Hungary)

机构地区：[1]Oncotherm Kft., Budars, Hungary [2]Department of Biotechnics, Hungarian University of Agriculture and Life Sciences, Gdll, Hungary

出　　处：《Open Journal of Biophysics》2024年第4期374-398,共25页生物物理学期刊（英文）

摘　　要：Modulated electro-hyperthermia (mEHT) is one of the novel oncological treatments with many preclinical and clinical results showing its advantages. The basis of the method is the synergy of thermal and nonthermal effects, similar to the thermal action of conventional hyperthermia combined with ionizing radiation (radiotherapy). The electric field and the radiofrequency current produced both the thermal and nonthermal processes. The thermal effects produce the elevated temperature as a thermal background to optimize the nonthermal impacts. The low frequency amplitude modulation ensures accurate targeting and promotes immunogenic cell death to develop the tumor specific memory T cells disrupting the malignant cells by immune surveillance. This process (abscopal effect) works like a vaccination. The low frequency amplitude modulation is combined in the new method with the high power pulses for short time, increasing the tumor distortion ability of the electric field. The new modulation combination has much deeper penetration triplicating the active thickness of the effective treatment. The short pulse absorption increases the safety and decreases the thermal toxicity of the treatment, making the treatment safer. The increased power allows for reduced treatment time with the prescribed dose.Modulated electro-hyperthermia (mEHT) is one of the novel oncological treatments with many preclinical and clinical results showing its advantages. The basis of the method is the synergy of thermal and nonthermal effects, similar to the thermal action of conventional hyperthermia combined with ionizing radiation (radiotherapy). The electric field and the radiofrequency current produced both the thermal and nonthermal processes. The thermal effects produce the elevated temperature as a thermal background to optimize the nonthermal impacts. The low frequency amplitude modulation ensures accurate targeting and promotes immunogenic cell death to develop the tumor specific memory T cells disrupting the malignant cells by immune surveillance. This process (abscopal effect) works like a vaccination. The low frequency amplitude modulation is combined in the new method with the high power pulses for short time, increasing the tumor distortion ability of the electric field. The new modulation combination has much deeper penetration triplicating the active thickness of the effective treatment. The short pulse absorption increases the safety and decreases the thermal toxicity of the treatment, making the treatment safer. The increased power allows for reduced treatment time with the prescribed dose.

关 键 词：Tumor Pulsed Modulation Nonthermal Excitation Thermal Homeostasis Cell-Killing RF Current Immunogenic Cell Death Apoptosis 

分 类 号：R73[医药卫生—肿瘤]