Enhancing Precision in Radiotherapy Delivery: Validating Monte Carlo Simulation Models for 6 MV Elekta Synergy Agility LINAC Photon Beam Using Two Models of the GAMOS Code  

作　　者：Nogaye Ndiaye Oumar Ndiaye Papa Macoumba Faye Kodjo Joël Fabrice N’Guessan Djicknack Dione Khady Sy Moussa Hamady Sy Jean Paul Latyr Faye Alassane Traoré Ababacar Sadikhe Ndao Nogaye Ndiaye;Oumar Ndiaye;Papa Macoumba Faye;Kodjo Joël Fabrice N’Guessan;Djicknack Dione;Khady Sy;Moussa Hamady Sy;Jean Paul Latyr Faye;Alassane Traoré;Ababacar Sadikhe Ndao(Institute of Applied Nuclear Technology, University Cheikh Anta Diop, Dakar, Senegal;International Cancer Center of Dakar, Dakar, Senegal;Department of Physics, Faculty of Sciences and Technology, University Cheikh Anta Diop, Dakar, Senegal)

机构地区：[1]Institute of Applied Nuclear Technology, University Cheikh Anta Diop, Dakar, Senegal [2]International Cancer Center of Dakar, Dakar, Senegal [3]Department of Physics, Faculty of Sciences and Technology, University Cheikh Anta Diop, Dakar, Senegal

出　　处：《World Journal of Nuclear Science and Technology》2024年第2期146-163,共18页核科学与技术国际期刊（英文）

摘　　要：The most crucial requirement in radiation therapy treatment planning is a fast and accurate treatment planning system that minimizes damage to healthy tissues surrounding cancer cells. The use of Monte Carlo toolkits has become indispensable for research aimed at precisely determining the dose in radiotherapy. Among the numerous algorithms developed in recent years, the GAMOS code, which utilizes the Geant4 toolkit for Monte Carlo simula-tions, incorporates various electromagnetic physics models and multiple scattering models for simulating particle interactions with matter. This makes it a valuable tool for dose calculations in medical applications and throughout the patient’s volume. The aim of this present work aims to vali-date the GAMOS code for the simulation of a 6 MV photon-beam output from the Elekta Synergy Agility linear accelerator. The simulation involves mod-eling the major components of the accelerator head and the interactions of the radiation beam with a homogeneous water phantom and particle information was collected following the modeling of the phase space. This space was po-sitioned under the X and Y jaws, utilizing three electromagnetic physics mod-els of the GAMOS code: Standard, Penelope, and Low-Energy, along with three multiple scattering models: Goudsmit-Saunderson, Urban, and Wentzel-VI. The obtained phase space file was used as a particle source to simulate dose distributions (depth-dose and dose profile) for field sizes of 5 × 5 cm² and 10 × 10 cm² at depths of 10 cm and 20 cm in a water phantom, with a source-surface distance (SSD) of 90 cm from the target. We compared the three electromagnetic physics models and the three multiple scattering mod-els of the GAMOS code to experimental results. Validation of our results was performed using the gamma index, with an acceptability criterion of 3% for the dose difference (DD) and 3 mm for the distance-to-agreement (DTA). We achieved agreements of 94% and 96%, respectively, between simulation and experimentation fThe most crucial requirement in radiation therapy treatment planning is a fast and accurate treatment planning system that minimizes damage to healthy tissues surrounding cancer cells. The use of Monte Carlo toolkits has become indispensable for research aimed at precisely determining the dose in radiotherapy. Among the numerous algorithms developed in recent years, the GAMOS code, which utilizes the Geant4 toolkit for Monte Carlo simula-tions, incorporates various electromagnetic physics models and multiple scattering models for simulating particle interactions with matter. This makes it a valuable tool for dose calculations in medical applications and throughout the patient’s volume. The aim of this present work aims to vali-date the GAMOS code for the simulation of a 6 MV photon-beam output from the Elekta Synergy Agility linear accelerator. The simulation involves mod-eling the major components of the accelerator head and the interactions of the radiation beam with a homogeneous water phantom and particle information was collected following the modeling of the phase space. This space was po-sitioned under the X and Y jaws, utilizing three electromagnetic physics mod-els of the GAMOS code: Standard, Penelope, and Low-Energy, along with three multiple scattering models: Goudsmit-Saunderson, Urban, and Wentzel-VI. The obtained phase space file was used as a particle source to simulate dose distributions (depth-dose and dose profile) for field sizes of 5 × 5 cm² and 10 × 10 cm² at depths of 10 cm and 20 cm in a water phantom, with a source-surface distance (SSD) of 90 cm from the target. We compared the three electromagnetic physics models and the three multiple scattering mod-els of the GAMOS code to experimental results. Validation of our results was performed using the gamma index, with an acceptability criterion of 3% for the dose difference (DD) and 3 mm for the distance-to-agreement (DTA). We achieved agreements of 94% and 96%, respectively, between simulation and experimentation f

关 键 词：GAMOS Monte Carlo LINAC RADIOTHERAPY Dose Distribution Phase Space Gamma Index 6 MV Photon Beam 

分 类 号：O57[理学—粒子物理与原子核物理]