Serologic Detection of <i>Toxoplasma gondii</i>in Cat Owners Residing at Dhaka Metropolitan Area of Bangladesh  

作　　者：Jerin-E- Gulshan Niladri Paul Atiqur Rahman Taibur Rahman Jerin-E- Gulshan;Niladri Paul;Atiqur Rahman;Taibur Rahman(Laboratory of Infection Biology, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh)

机构地区：[1]Laboratory of Infection Biology, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh

出　　处：《Advances in Microbiology》2021年第5期257-265,共9页微生物学（英文）

摘　　要：<i>Toxoplasma gondii</i> is a zoonotic protozoan that can infect any warm-blooded mammal. <i>T. gondii</i> infects about one-third of the human population on the planet. Infection with the parasite in human causes toxoplasmosis that may pose a high risk in immunocompromised individuals under certain clinical conditions. Cats are the ultimate hosts of <i>T. gondii</i> where oocysts are formed through mating of male and female gametes. Infected cats can expel <i>T. gondii</i> oocysts in their feces, and thereby capable of pass on a disease to humans and other animals through consumption of foods, vegetables and water that are polluted with cat feces. The study was conducted to detect the presence of anti-<i>T. gondii</i> IgM and IgG antibodies in the blood of individuals with or without cat contact to determine if there is any relationship between cat contacts and <i>T. gondii</i> infection in humans. To address this, we enrolled subjects who contacted with the cat as target group and individuals with no cat contact as control group. Following register of different demographic data (including age, sex, education, foods habit, income status, etc.), whole blood from each enrolled subject of both the target group and control group was collected for serum preparation. <i>T. gondii</i> infected subjects were detected by Toxo Rapid test kit through identifying anti-<i>T. gondii</i> IgM and IgG antibodies in their serum. We found that only three out of twenty subjects who were in contact with cat showed positive IgG response while IgM antibody response was absent for all subjects. When compared with the data from control group, we did not find any significant association (p = 0.33) of cat contact with the transmission <i>of T. gondii</i> into human. However, with this small number of study subjects, we cannot conclusively say that there is no impact of cat contact on the transmission of <i>T. gondii</i> into human. Whether any association exists or not can be ascertained with a large number of subjects from different area<i>Toxoplasma gondii</i> is a zoonotic protozoan that can infect any warm-blooded mammal. <i>T. gondii</i> infects about one-third of the human population on the planet. Infection with the parasite in human causes toxoplasmosis that may pose a high risk in immunocompromised individuals under certain clinical conditions. Cats are the ultimate hosts of <i>T. gondii</i> where oocysts are formed through mating of male and female gametes. Infected cats can expel <i>T. gondii</i> oocysts in their feces, and thereby capable of pass on a disease to humans and other animals through consumption of foods, vegetables and water that are polluted with cat feces. The study was conducted to detect the presence of anti-<i>T. gondii</i> IgM and IgG antibodies in the blood of individuals with or without cat contact to determine if there is any relationship between cat contacts and <i>T. gondii</i> infection in humans. To address this, we enrolled subjects who contacted with the cat as target group and individuals with no cat contact as control group. Following register of different demographic data (including age, sex, education, foods habit, income status, etc.), whole blood from each enrolled subject of both the target group and control group was collected for serum preparation. <i>T. gondii</i> infected subjects were detected by Toxo Rapid test kit through identifying anti-<i>T. gondii</i> IgM and IgG antibodies in their serum. We found that only three out of twenty subjects who were in contact with cat showed positive IgG response while IgM antibody response was absent for all subjects. When compared with the data from control group, we did not find any significant association (p = 0.33) of cat contact with the transmission <i>of T. gondii</i> into human. However, with this small number of study subjects, we cannot conclusively say that there is no impact of cat contact on the transmission of <i>T. gondii</i> into human. Whether any association exists or not can be ascertained with a large number of subjects from different area

关 键 词：Toxoplasma gondii Cat Owner SEROPOSITIVITY Transmission 

分 类 号：R73[医药卫生—肿瘤]