Essential Oils from Mentha viridis(L).L.and Mentha pulegium L.:Cytogenotoxic Effects on Human Cells  

作　　者：Lucilene Fernandes Silva Maria das Gracas Cardoso Paulo Sérgio Castilho Preté Maria Luisa Teixeira David Lee Nelson Maísa Lamounier Magalhaes Vanuzia Rodrigues Fernandes Ferreira Rafaela Vieira Souza Luana Isac Soares Silvana Marcussi 

机构地区：[1]Departamento de Química,Universidade Federal de Lavras,Campus Universitário,Lavras,Minas Gerais,Brasil [2]Departamento de Química,Universidade Federal dos Vales do Jequitinhonha e Mucuri,Campus Universitário,Diamantina,Minas Gerais,Brasil [3]Departamento de Ciência dos Alimentos,Universidade Federal de Lavras,Campus Universitário,Lavras,Minas Gerais,Brasil

出　　处：《American Journal of Plant Sciences》2017年第6期1423-1437,共15页美国植物学期刊（英文）

基　　金：the support of the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico(CNPq); the Fundacao de Amparo a Pesquisa do Estado de Minas Gerais(FAPEMIG)for financial support ; the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior(CAPES)for a PVNS.

摘　　要：The essential oils from Mentha viridis (L). L. and Mentha pulegium L. were studied to assess their inhibitory potential on phospholipase from snake venoms and to determine their cytogenotoxic action on human cells. These essential oils were able to inhibit the breakdown of phospholipids induced by venoms of snakes of the Bothrops genus. Both oils presented hemolytic activity, although the Mentha viridis (L). L. oil induced hemolysis only at the highest concentrations (14.6 and 29 μL&#183mL-1). The essential oil from M. viridis induced 3.9;8.6 and 16.2 times greater damage to human leukocyte DNA than that observed with the positive control (100 μg&#183μL-1 doxorubicin) at concentrations of 0.25;0.5 and 1.0 μL&#183mL-1, respectively. A similar effect was observed for the oil from M. pulegium (2.1, 2.5 and 15.8 times greater damage). The results extend the characterization of these essential oils and demonstrate their potential use in industries.The essential oils from Mentha viridis (L). L. and Mentha pulegium L. were studied to assess their inhibitory potential on phospholipase from snake venoms and to determine their cytogenotoxic action on human cells. These essential oils were able to inhibit the breakdown of phospholipids induced by venoms of snakes of the Bothrops genus. Both oils presented hemolytic activity, although the Mentha viridis (L). L. oil induced hemolysis only at the highest concentrations (14.6 and 29 μL&#183mL-1). The essential oil from M. viridis induced 3.9;8.6 and 16.2 times greater damage to human leukocyte DNA than that observed with the positive control (100 μg&#183μL-1 doxorubicin) at concentrations of 0.25;0.5 and 1.0 μL&#183mL-1, respectively. A similar effect was observed for the oil from M. pulegium (2.1, 2.5 and 15.8 times greater damage). The results extend the characterization of these essential oils and demonstrate their potential use in industries.

关 键 词：Essential Oils Mentha viridis(L).L. Mentha pulegium L. HEMOLYSIS Comet Assay 

分 类 号：R73[医药卫生—肿瘤]