A Bioprocessed Black Rice Bran Glutathione-Enriched Yeast Extract Protects Rats and Mice against Alcohol-Induced Hangovers  

作　　者：Sung Phil Kim Ju Ryeong Lee Ki Sun Kwon Yeo Jin Jang Jeanman Kim Keun Hyung Yu Sun Yeop Lee Mendel Friedman Sung Phil Kim;Ju Ryeong Lee;Ki Sun Kwon;Yeo Jin Jang;Jeanman Kim;Keun Hyung Yu;Sun Yeop Lee;Mendel Friedman(STR Biotech Co., Ltd., Chuncheon, Republic of Korea;Department of Technical Development, Chuncheon Bioindustry Foundation, Chuncheon, Republic of Korea;Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, CA, USA)

机构地区：[1]STR Biotech Co., Ltd., Chuncheon, Republic of Korea [2]Department of Technical Development, Chuncheon Bioindustry Foundation, Chuncheon, Republic of Korea [3]Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, CA, USA

出　　处：《Food and Nutrition Sciences》2021年第3期223-238,共16页食品与营养科学（英文）

摘　　要：Human and animal alcohol-induced hangovers are caused by adverse effects of acetaldehyde formed </span><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">in</span></i><span style="font-family:Verdana;"> <i>vivo</i></span><i><span style="font-family:Verdana;"></i></span></i><span style="font-family:Verdana;"> by the enzymatic oxidation of ethyl alcohol to acetaldehyde. This study aims to determine the effect of the combination of a bioprocessed black rice bran (BRB-F) and glutathione-enriched yeast extract (GEYE) on hangovers as tested in rats and mice. Because analysis by HPLC showed that the content of the biologically active rice bran compound </span><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">γ</span></i><i><span style="font-family:Verdana;"></i></span></i><span style="font-family:Verdana;">-oryzanol as well as of the antioxidant reduced glutathione were unaffected during the preparation of tablets containing 100 mg/kg of the bran formulation, the tablets were then administered orally to rats. The results showed decreased blood concentrations of both alcohol and acetaldehyde compared to the control group. Additional behavior experiments using the Rota-rod and wire tests in mice confirmed that the food formulation relieved hangover behavior caused by alcohol. It seems that the combination of BRB-F and GEYE can effectively control hangovers in rodents caused by alcohol intake. Mechanistic aspects of the hangover and anti-hangover effects of alcohol-derived acetaldehyde are similar to browning-type reactions between the aldehyde group of glucose and proteins, the antibiotic effects of cinnamaldehyde against pathogenic bacteria, the adverse effects of the heat-induced food toxin acrylamide, and the alkali-induced formation of the unnatural amino acid lysinoalanine.Human and animal alcohol-induced hangovers are caused by adverse effects of acetaldehyde formed </span><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">in</span></i><span style="font-family:Verdana;"> <i>vivo</i></span><i><span style="font-family:Verdana;"></i></span></i><span style="font-family:Verdana;"> by the enzymatic oxidation of ethyl alcohol to acetaldehyde. This study aims to determine the effect of the combination of a bioprocessed black rice bran (BRB-F) and glutathione-enriched yeast extract (GEYE) on hangovers as tested in rats and mice. Because analysis by HPLC showed that the content of the biologically active rice bran compound </span><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">γ</span></i><i><span style="font-family:Verdana;"></i></span></i><span style="font-family:Verdana;">-oryzanol as well as of the antioxidant reduced glutathione were unaffected during the preparation of tablets containing 100 mg/kg of the bran formulation, the tablets were then administered orally to rats. The results showed decreased blood concentrations of both alcohol and acetaldehyde compared to the control group. Additional behavior experiments using the Rota-rod and wire tests in mice confirmed that the food formulation relieved hangover behavior caused by alcohol. It seems that the combination of BRB-F and GEYE can effectively control hangovers in rodents caused by alcohol intake. Mechanistic aspects of the hangover and anti-hangover effects of alcohol-derived acetaldehyde are similar to browning-type reactions between the aldehyde group of glucose and proteins, the antibiotic effects of cinnamaldehyde against pathogenic bacteria, the adverse effects of the heat-induced food toxin acrylamide, and the alkali-induced formation of the unnatural amino acid lysinoalanine.

关 键 词：ALCOHOL ACETALDEHYDE Hangover Inhibition Black Rice Bran RODENTS Mechanisms 

分 类 号：O62[理学—有机化学]