Synthesis Characterization and Biological Activities of an Enamine Derivative and Its Coordination Compounds  

作　　者：Temitayo Aiyelabola Johannes Jordaan Daniel Otto Ezekiel Akinkunmi Temitayo Aiyelabola;Johannes Jordaan;Daniel Otto;Ezekiel Akinkunmi(Department of Chemistry, Obafemi Awolowo University, Ife, Nigeria;Research Focus Area for Chemical Resource Beneficiation, Laboratory for Analytical Services, North-West University, Potchefstroom, South Africa;Department of Pharmaceutics, Obafemi Awolowo University, Ife, Nigeria)

机构地区：[1]Department of Chemistry, Obafemi Awolowo University, Ife, Nigeria [2]Research Focus Area for Chemical Resource Beneficiation, Laboratory for Analytical Services, North-West University, Potchefstroom, South Africa [3]Department of Pharmaceutics, Obafemi Awolowo University, Ife, Nigeria

出　　处：《Advances in Biological Chemistry》2020年第6期172-189,共18页生物化学进展（英文）

摘　　要：<span style='font-family:Verdana;font-size:12px;'>The medicinal uses and applications of metal complexes are of increasing clinical and commercial importance;this is as a result of some level of success </span><span style='font-family:Verdana;font-size:12px;'>achieved so far. In this regard, novel enamine free-base ligands were synthesized</span><span style='font-family:Verdana;font-size:12px;'> by the condensation of terephthalaldehyde and 2-(methylamino)ethanol. This afforded a dinegative </span><i><span style='font-family:Verdana;font-size:12px;'>ONNO</span></i><span style='font-family:Verdana;font-size:12px;'> donor enamine, free base, characterized using </span>^{<span style='font-family:Verdana;font-size:12px;'>1</span>}<span style='font-family:Verdana;font-size:12px;'>H and </span>^{<span style='font-family:Verdana;font-size:12px;'>13</span>}<span style='font-family:Verdana;font-size:12px;'>C NMR, Fourier-transformed infrared and UV-vis spectroscopy. Coordination compounds of the enamine were also synthesized using Cu(II), Ni(II), Co(II) and VO(IV) ions. These complexes were characterized by electronic, IR spectrophotometry, mass spectrometry, magnetic susceptibility and </span><span style='font-family:Verdana;font-size:12px;'>E</span><span style='font-family:Verdana;font-size:12px;'>DX. The compounds were thereafter evaluated for their antimicrobial and cytotoxic activities. The data obtained w</span><span style='font-size:12px;font-family:Verdana;'>ere</span><span style='font-size:12px;font-family:Verdana;'> supportive of a</span><span style='font-size:12px;font-family:Verdana;'>n</span><span style='font-size:10.0pt;font-family:''><span style='font-family:Verdana;font-size:12px;'> octahedral geometry</span><span style='font-family:Verdana;font-size:12px;'> for the Cu(II) complex, a square-pyramidal geometry for the vanadium complex and a 4-coordinate square-planar geometry for both the cobalt and nickel complexes. The magnetic susceptibility data revealed that the complexes are magnetical<span style='font-family:Verdana;font-size:12px;'>The medicinal uses and applications of metal complexes are of increasing clinical and commercial importance;this is as a result of some level of success </span><span style='font-family:Verdana;font-size:12px;'>achieved so far. In this regard, novel enamine free-base ligands were synthesized</span><span style='font-family:Verdana;font-size:12px;'> by the condensation of terephthalaldehyde and 2-(methylamino)ethanol. This afforded a dinegative </span><i><span style='font-family:Verdana;font-size:12px;'>ONNO</span></i><span style='font-family:Verdana;font-size:12px;'> donor enamine, free base, characterized using </span>^{<span style='font-family:Verdana;font-size:12px;'>1</span>}<span style='font-family:Verdana;font-size:12px;'>H and </span>^{<span style='font-family:Verdana;font-size:12px;'>13</span>}<span style='font-family:Verdana;font-size:12px;'>C NMR, Fourier-transformed infrared and UV-vis spectroscopy. Coordination compounds of the enamine were also synthesized using Cu(II), Ni(II), Co(II) and VO(IV) ions. These complexes were characterized by electronic, IR spectrophotometry, mass spectrometry, magnetic susceptibility and </span><span style='font-family:Verdana;font-size:12px;'>E</span><span style='font-family:Verdana;font-size:12px;'>DX. The compounds were thereafter evaluated for their antimicrobial and cytotoxic activities. The data obtained w</span><span style='font-size:12px;font-family:Verdana;'>ere</span><span style='font-size:12px;font-family:Verdana;'> supportive of a</span><span style='font-size:12px;font-family:Verdana;'>n</span><span style='font-size:10.0pt;font-family:''><span style='font-family:Verdana;font-size:12px;'> octahedral geometry</span><span style='font-family:Verdana;font-size:12px;'> for the Cu(II) complex, a square-pyramidal geometry for the vanadium complex and a 4-coordinate square-planar geometry for both the cobalt and nickel complexes. The magnetic susceptibility data revealed that the complexes are magnetical

关 键 词：ENAMINE Nuclear Magnetic Resonance Antimicrobial Activity CYTOTOXICITY EDX Therapeutic Coordination Compound Brine Shrimp Lethality Bioassay 

分 类 号：O62[理学—有机化学]