Application of TIRFM in Biomolecule Research and Clinical Medicine  

作　　者：Yexi Zhang Yexi Zhang(College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, China)

机构地区：[1]College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, China

出　　处：《Advances in Biological Chemistry》2021年第5期206-219,共14页生物化学进展（英文）

摘　　要：<span style="font-family:Verdana;">With the increasing demand for imaging quality, many scientists constantly explore new imaging instruments to meet the requirements. The total internal reflection fluorescence microscopy has some incomparable </span><span style="font-family:Verdana;"><span style="font-family:Verdana;">superiorities</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">, so it has become one of the research hotspots in recent years. It can show great performance in single-molecule imaging because it has unique imaging principles. This apparatus is used mainly in two fields, biomolecule research and clinical medicine. To know this instrument’s function, the summary of application</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"> in these two parts was given in this article. Now, scientists who ha</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">ve</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"> been focusing on this apparatus try to </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">make</span></span><span><span style="font-family:""><span style="font-family:Verdana;"> this microscope combined with other late-model precise instruments that probe some unknown interac</span><span style="font-family:Verdana;">tion mechanism of action. The TIRFM will show extraordinary talents in</span><span style="font-family:Verdana;"> many aspects, and it will become a powerful tool for people to explore the mysteries of life.</span></span></span><span style="font-family:Verdana;">With the increasing demand for imaging quality, many scientists constantly explore new imaging instruments to meet the requirements. The total internal reflection fluorescence microscopy has some incomparable </span><span style="font-family:Verdana;"><span style="font-family:Verdana;">superiorities</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">, so it has become one of the research hotspots in recent years. It can show great performance in single-molecule imaging because it has unique imaging principles. This apparatus is used mainly in two fields, biomolecule research and clinical medicine. To know this instrument’s function, the summary of application</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"> in these two parts was given in this article. Now, scientists who ha</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">ve</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"> been focusing on this apparatus try to </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">make</span></span><span><span style="font-family:""><span style="font-family:Verdana;"> this microscope combined with other late-model precise instruments that probe some unknown interac</span><span style="font-family:Verdana;">tion mechanism of action. The TIRFM will show extraordinary talents in</span><span style="font-family:Verdana;"> many aspects, and it will become a powerful tool for people to explore the mysteries of life.</span></span></span>

关 键 词：TIRFM Single-Molecule Detection Dynamic Imaging Fluorescence Sensor 

分 类 号：O17[理学—数学]