Facile Synthesis of Novel Chiral Bicyclic Thioureas and Their Crystal Structures  

作　　者：Ping An Wang Hui Fang Nie Lin Jie Yan Sheng Yong Zhang 

机构地区：[1]Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Xi’an, China

出　　处：《International Journal of Organic Chemistry》2012年第1期15-20,共6页有机化学国际期刊（英文）

摘　　要：The novel well-defined chiral bicyclic thioureas based on enantiopure unsymmetric cis-2,5-disustituted pyrrolidine skeleton were firstly synthesized and fully characterized by their 1H NMR, 13C NMR and HRMS. Their absolute configurations were also determined by single-crystal X-ray analysis.The novel well-defined chiral bicyclic thioureas based on enantiopure unsymmetric cis-2,5-disustituted pyrrolidine skeleton were firstly synthesized and fully characterized by their 1H NMR, 13C NMR and HRMS. Their absolute configurations were also determined by single-crystal X-ray analysis.

关 键 词：CHIRAL BICYCLIC THIOUREA cis-2 5-Disubstituted PYRROLIDINE X-Ray Analysis 

分 类 号：O6[理学—化学]