PYRROLIDINE

作品数:54被引量:56H指数:3
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相关领域:理学医药卫生更多>>
相关作者:姚祝军王春江倪轶轲宋晓男刘康更多>>
相关机构:中国科学院中国科学院大学西华师范大学武汉大学更多>>
相关期刊:《Progress in Natural Science:Materials International》《Chinese Journal of Catalysis》《Asian Pacific Journal of Tropical Biomedicine》《Chinese Journal of Chemistry》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划河南省自然科学基金更多>>
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Pyrrole and pyrrolidine analogs:The promising scaffold in discovery of pesticides
《Chinese Chemical Letters》2025年第3期113-124,共12页Anjing Liao Wei Sun Yaming Liu Han Yan Zhi Xia Jian Wu 
financial support from the National Natural Science Foundation of China(No.32072445);the Science and Technology Plan Project of Guizhou Province(Qiankehezhicheng[2024]the general 083);the Program of Introducing Talents to Chinese Universities(No.D20023);the Central Government Guides Local Science and Technology Development Fund Projects(Qiankehezhongyindi(2023)001);Key Agricultural Technology R&D Projects of the Xinjiang Production and Construction Corps(NYHXGG,2023AA602);the Frontiers Science Centre for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province[Qianjiaohe KY(2020)004];the specific research fund of The Innovation Platform for Academicians of Hainan Province(No.SQ2020PTZ0009);。
Pyrrole is a heterocycle with four carbon atoms and a nitrogen atom,which is extensively used in the pesticide and pharmaceutical industries.In addition,it has a series of analogs such as pyrrolidine,pyrroline,and pyr...
关键词:PYRROLE PYRROLIDONE Agrochemicals Biological activity Structure-activity relationship 
Targeted isolation and identification of bioactive pyrrolidine alkaloids from Codonopsis pilosula using characteristic fragmentation-assisted mass spectral networking被引量:1
《Chinese Journal of Natural Medicines》2022年第12期948-960,共13页TANG Xiyang FAN Cailian ZENG Jiaxing ZHAO Pengcheng WANG Xiaoxing CAI Wanjun LI Ting DAI Yi YAO Zhihong YAO Xinsheng 
The work was supported by the Science and Technology Projects in Guangzhou(No.202201010484)。
Codonopsis pilosula(CP),a well-known food medicine homology plant,is commonly used in many countries.In our preliminary study,a series of pyrrolidine alkaloids with high MS responses were detected as characteristic ab...
关键词:Codonopsis pilosula(CP) Targeted isolation UPLC/Q-TOF MS Characteristic fragmentation-assisted mass spectral networking Pyrrolidine alkaloids Lipid-lowering activity 
Evolution of catalytic activity driven by structural fusion of icosahedral gold cluster cores
《Chinese Journal of Catalysis》2021年第2期245-250,共6页Dan Yang Yan Zhu 
国家自然科学基金(21773109,91845104).
Atomically precise gold cluster catalysts have emerged as a new frontier in catalysis science,owing to their unexpected catalytic properties.In this work,we explore the evolution of the catalytic activity of clusters ...
关键词:Gold cluster Structure fusion Icosahedral unit Oxidation of pyrrolidine Active sites Catalytic activity 
An Aminopyrrolidinyl Phosphonates—A New Class of Antibiotics: Facile Synthesis and Predicted Biological Activity
《International Journal of Organic Chemistry》2020年第4期170-181,共12页Abed Al Aziz Al Quntar Hasan Dweik Ahmad Jabareen Tatyana A. Gloriozova Valery M. Dembitsky 
A novel class of aminopyrrolidinyl phosphonates was synthesized in 74% - 80% isolated yield by the addition of three-fold excess of primary amines to diethyl 4-chloro-1-butynylphosphonates. The reaction was carried ou...
关键词:Alkynylphosphonates CYCLIZATION PYRROLIDINE β-Aminophosphonates Amine Addition ANTIBIOTICS 
Silicon-mediated enantioselective synthesis of structurally diverseα-amino acid derivatives
《Science China Chemistry》2020年第8期1082-1090,共9页Jun-Han Ma Li Li Yu-Li Sun Zheng Xu Xing-Feng Bai Ke-Fang Yang Jian Cao Yu-Ming Cui Guan-Wu Yin Li-Wen Xu 
supported by the National Natural Science Foundation of China(21773051,21702211,21703051);Zhejiang Provincial Natural Science Foundation of China(LZ18B020001,LQ19B040001,LY18B020013);the Hangzhou Science and Technology Bureau of China(20180432B05)。
The catalytic asymmetric synthesis of novel and chiral amino acid derivatives with unconventional chemo-,diastereo-,and enantio-selectivity remains a paramount challenge.Herein we reported a novel protocol for the use...
关键词:(3+2)cycloaddition asymmetric catalysis acylsilane PYRROLIDINE amino aldehyde amino acids 
Infrared Spectroscopy of Neutral and Cationic Pyrrolidine Monomer in Supersonic Jet被引量:1
《Chinese Journal of Chemical Physics》2020年第1期43-47,I0005,I0006,共7页Min Xie Zhao-li Zhang Yu Zhang Xiao-nan Sun Fu-fei Sun Yong-jun Hu 
the National Natural Science Foundation of China(No.U1732146,No.21273083);the Project under Scientific and Technological Planning Grant(No.201805010002)by Guangzhou City.
Pyrrolidine,a five membered heterocyclic molecule,is widely existing in organism.Herein,infrared spectra of pyrrolidine monomer in neutral and cationic states were obtained by vacuum ultraviolet ionization,infrared ph...
关键词:IR spectroscopy HYPERCONJUGATION Cationic state CH bond acidity Gas phase 
Towards eradicating antibiotic-resistant bacteria: synthesis and antibacterial activities of substituted N-(2-nitrophenyl)pyrrolidine-and piperidine-2-carboxylic acids
《Journal of Chinese Pharmaceutical Sciences》2019年第10期704-715,共12页Jocelyn A.Odusami Monisola I.Ikhile Marthe C.D.Fotsing Idris A.O.lasupo Josephat U.Izunobi Elizabeth O.Bamgbade Thierry Y.Fonkui Olayinka T.Asekun Oluwole B.Familoni Derek T.Ndinteh 
Department of Applied Chemistry,Faculty of Science,University of Johannesburg for providing chemicals and running cost for this project through the National Research Foundation(NRF)
Antibacterial resistance is a source of great concern in the effective prevention and treatment of infections caused by bacteria,making the development of requisite therapeutics a major challenge.N-(Nitrophenyl)cycloa...
关键词:ANTIBIOTICS Bacteria Cyclic amino ACIDS o-Halogenonitrobenzene 
Pyrrolidine dithiocarbamate and saxagliptin ameliorate ulcerative colitis in rats被引量:1
《Asian Pacific Journal of Tropical Biomedicine》2019年第9期373-380,共8页Berween Mahmoud Elmahmoudy Mai A.Abd El Fattah Mohamed F.Elyamany Laila A.Rashed 
Objective: To evaluate the antioxidant, immunomodulatory and anti-inflammatory activities of pyrrolidine dithiocarbamate and saxagliptin in rats with thioacetamide-induced ulcerative colitis. Methods: Animals were ora...
关键词:ULCERATIVE colitis Inflammatory MEDIATORS Oxidative stress PYRROLIDINE DITHIOCARBAMATE SAXAGLIPTIN THIOACETAMIDE 
Synthesis of N-alkyl substituted iminosugars from D-ribose
《Chinese Chemical Letters》2018年第1期73-75,共3页Haibo Wang Yang Pan Qin Tang Wei Zou Huawu Shao 
supported by the Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Programme of Chinese Academy of Sciences(No. ZSTH-006);the National Natural Science Foundation of China(Nos. 21372215 and 21772192);Chinese Academy of Sciences(No.KFJ-SW-STS-143-1)
An effective and facile method for the synthesis of N-alkylated hydroxylpyrrolidine and hydroxylpiper- idine is described, A number of N-alkyl substituted iminosugars were prepared using iodine-induced intramolecular ...
关键词:lminosugar PYRROLIDINE PIPERIDINE GLYCOSIDASE D-RIBOSE 
Asymmetric catalyzed intramolecular aza-Michael reaction mediated by quinine-derived primary amines
《Chinese Chemical Letters》2017年第8期1793-1797,共5页Xian-Dong Zhai Zhong-Duo Yang Zhi Luo Hong-Tao Xu 
financial support from the National Natural Science Foundation of China (No. 21262022)
An intramolecular organocatalytic enantioselective aza-Michael reaction of carbamates, sulfonamides and acetamides to a,b-unsaturated ketones was developed. This process is promoted by 9-amino-9-deoxy-epi-quinine and ...
关键词:Asymmetric catalysis Intramolecular aza-Michael reaction Primary amine Five-and six-membered heterocycles Pyrrolidine and piperidine Enantioselective organocatalytic 
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