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Combination therapy with saxagliptin and vitamin D for the preservation ofβ-cell function in adult-onset type 1 diabetes:a multi-center,randomized,controlled trial被引量：3: 《Signal Transduction and Targeted Therapy》2023年第5期2354-2362,共9页Xiang Yan Xia Li Bingwen Liu Jiaqi Huang Yufei Xiang Yuhang Hu Xiaohan Tang Ziwei Zhang Gan Huang Zhiguo Xie Houde Zhou Zhenqi Liu Xiangbing Wang Richard David Leslie Zhiguang Zhou; Disease modifying therapies aiming to preserveβ-cell function in patients with adult-onset autoimmune type 1 diabetes are lacking.Here,we conducted a multi-centre,randomized,controlled trial to assess theβ-cell pres...; 关键词：VITAMIN ALONE treatment

A PK/PD model of saxagliptin:to simulate its pharmacokinetics and pharmacodynamics in healthy adults and patients with impaired hepatic function被引量：1: 《Journal of Chinese Pharmaceutical Sciences》2021年第2期119-132,共14页Lu Shi Feng Miao Guopeng Wang Wenyan Sun Yang Liu; In this study,we aimed to develop and evaluate a whole-body physiologically based pharmacokinetic(WB-PBPK)/pharmacodynamic(PD)model for saxagliptin,simulate its pharmacokinetic and pharmacodynamic properties in health...; 关键词：PK/PD modeling Hepatic impairment SAXAGLIPTIN GastroPlus

Pyrrolidine dithiocarbamate and saxagliptin ameliorate ulcerative colitis in rats被引量：1: 《Asian Pacific Journal of Tropical Biomedicine》2019年第9期373-380,共8页Berween Mahmoud Elmahmoudy Mai A.Abd El Fattah Mohamed F.Elyamany Laila A.Rashed; Objective: To evaluate the antioxidant, immunomodulatory and anti-inflammatory activities of pyrrolidine dithiocarbamate and saxagliptin in rats with thioacetamide-induced ulcerative colitis. Methods: Animals were ora...; 关键词：ULCERATIVE colitis Inflammatory MEDIATORS Oxidative stress PYRROLIDINE DITHIOCARBAMATE SAXAGLIPTIN THIOACETAMIDE

Drug interactions of dipeptidyl peptidase 4 inhibitors involving CYP enzymes and P-gp efflux pump: 《World Journal of Meta-Analysis》2019年第4期156-161,共6页Naina Mohamed Pakkir Maideen; Dipeptidyl peptidase 4(DPP4) inhibitors are oral antidiabetic drugs approved to manage type 2 diabetes mellitus. Saxagliptin is a substrate of CYP3A4/5 enzymes while other DPP4 inhibitors such as sitagliptin, linaglip...; 关键词：Drug interactions SITAGLIPTIN SAXAGLIPTIN LINAGLIPTIN Gemigliptin Teneligliptin VILDAGLIPTIN Anagliptin CYP3A4 P-GP EFFLUX pump

EMA批准抗糖尿病药Saxagliptin/Dapagliflozin新复方片剂上市: 《中国执业药师》2016年第10期56-56,共1页; 欧洲药品评审局（EMA）于2016年7月15日批准阿斯利康（Astrazeneca）公司的Saxagliptin/Dapagliflozin（参考译名：沙格列汀/达格列净,商品名：Qtern）片剂上市,用于18岁及以上2型糖尿病患者改善血糖控制,患者采用二甲双胍和（或）磺脲...; 关键词：EMA 商品名抗糖尿病药格列沙格双胍二甲阿斯利康肠促胰岛素磺脲类药物

Efficacy and safety of saxagliptin in patients with type 2 diabetes mellitus:a meta-analysis of randomized controlled trials被引量：2: 《Journal of Chinese Pharmaceutical Sciences》2016年第2期128-139,共12页姚莉范芳芳胡兰赵生俊郑丽丽; Xinjiang Medical University Scientific Research and Innovation Foundation(Grant No.XYDCX2014117); As a new oral hypoglycemic agent, saxagliptin belongs to the class of dipeptidyl peptidase-4 （DPP-4） inhibitors. However, it remains inconclusive whether saxagliptin is associated with increased risk of adverse even...; 关键词：DPP-4 inhibitor SAXAGLIPTIN META-ANALYSIS Type 2 diabetes mellitus Fasting plasma glucose Glycosylated hemoglobin Randomized controlled trial HYPOGLYCAEMIA

Development and Validation of a Method for Simultaneous Determination of Metformin and Saxagliptin in a Formulation by RP-HPLC: 《American Journal of Analytical Chemistry》2015年第11期841-850,共10页P. B. N. Prasad K. Satyanaryana G. Krishnamohan; A simple, specific, sensitive, precise and accurate reverse phase high performance liquid chromatographic method (RP-HPLC) was developed for the simultaneous analysis of Metformin and Saxagliptin in active pharmaceuti...; 关键词：METFORMIN SAXAGLIPTIN SIMULTANEOUS Analysis RP-HPLC Stress Induced DEGRADATION

Development and Validation of a High Performance Thin Layer Chromatographic Method for Quantitative Analysis of Saxagliptin: 《American Journal of Analytical Chemistry》2015年第10期797-806,共10页Salvala Srividya Ettireddy Swetha Ciddi Veeresham; A simple, specific, accurate and precise high performance thin layer chromatographic method (HPTLC) was developed for the quantitative analysis of Saxagliptin in active pharmaceutical ingredients (APIs) and pharmaceut...; 关键词：HPTLC SAXAGLIPTIN QUANTITATIVE Analysis Stress Induced DEGRADATION VALIDATION API

The Efficacy and Safety of Saxagliptin in Haemodialysis Patients: 《Open Journal of Nephrology》2013年第2期83-88,共6页Abdul Halim Abdul Gafor Azrina Abdul Kadir Rizna Abdul Cader Rozita Mohd Kong Wei Yen Rohana Abdul Ghani Shamsul Azhar Shah Norella C. T. Kong; Introduction: Good glycaemic control without causing excessive hypoglycaemia reduced the risk of macrovascular and microvascular complications in type 2 DM patients on regular haemodialysis (HD). The objectives of thi...; 关键词：FRUCTOSAMINE FASTING Blood Sugar HbA1c HAEMODIALYSIS SAXAGLIPTIN Type 2 Diabetes MELLITUS

治疗2型糖尿病新药——Saxagliptin被引量：6: 《中国药房》2010年第1期80-82,共3页刘萍周箐杨小军李劲程立宇; 目前，糖尿病已成为全球主要的健康问题。虽然治疗糖尿病的药物种类及数量均较多，但其导致的高死亡率已反映出现在的治疗方法并不能充分、有效地控制血糖水平，且其中多数药物都不可避免地会出现副作用，如致患者体质量增加、低血糖症...; 关键词：2型糖尿病治疗方法新药药物种类体质量增加健康问题高死亡率血糖水平

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