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Efficacy of Bee Products(Anzer Honey,Pollen and Propolis)in Detection and Healing of Damage Induced by Antidiabetic Drug Vildagliptin/Metformin Hydrochloride in Healthy Human Pancreatic Cells:Cytotoxic,Genotoxic and Biochemical Studies: 《Current Medical Science》2023年第6期1173-1182,共10页ÖzlemÖzdemir ZinetÇöl Ömer Ertürk; Ordu University Scientific Project Coordination Department(ODUBAP,No.B-2139).; Background and Objective Although drugs are powerful therapeutic agents,they have a range of side effects.These side effects are sometimes cellular and not clinically noticeable.Vildagliptin/metformin hydrochloride is...; 关键词：cell viability hTERT-HPNE Anzer bee products drug side effect diabetes mellitus

Short-Term Effects of Liraglutide versus Vildagliptin on Insulin Secretion and Sensitivity in Type 2 Diabetes: A Single Blinded Randomized Controlled Trial (LIRAVIS Study)被引量：1: 《Journal of Diabetes Mellitus》2023年第1期45-57,共13页Martine Claude Etoa Etoga Estelle Amandine Well Simeon Pierre Choukem Mesmin Dehayem Francine Mendane Mekobe Anne Boli Ongmeb Astasselbe Hadja Inna Jean Claude Mbanya Eugene Sobngwi; Background: We aimed to evaluate the short-term metabolic effects of a GLP-1a, (liraglutide) versus a DPP-4i, (vildagliptin) in a group of sub-Saharan type 2 diabetes patients. Methods: We conducted a randomized contr...; 关键词：Insulin Sensitivity Insulin Secretion LIRAGLUTIDE VILDAGLIPTIN Incretinomimetics

Anti-cancer effects of sitagliptin,vildagliptin,and exendin-4 on triple-negative breast cancer cells via mitochondrial modulation: 《BIOCELL》2022年第12期2645-2657,共13页POOJA JAISWAL VERSHA TRIPATHI ANSHUL ASSAIYA DHARMENDRA KASHYAP RAHUL DUBEY ANAMIKA SINGH JANESH KUMAR HEM CHANDRA JHA RAJESH SHARMA AMIT KUMAR DIXIT HAMENDRA SINGH PARMAR; The work was supported by the Council of Scientific and Industrial Research-Junior Research Fellowship to Ms.Pooja Jaiswal(File No.09/301(0137)/2019-EMR-I);Ms.Versha Tripathi(09/301(0138)/2019-EMR-I);We also acknowledge the India-Belarus joint project(DST/INT/BLR/P-24/2019)funded by the Department of Science and Technology;New Delhi and the research grant from Devi Ahilya University,Indore(Dev/Seedmoney2.0/2020-21/655)sanctioned to Dr.Hamendra Singh Parmar.; Triple-negative breast cancer(TNBC)cell line MDA-MB-231 is known for Warburg metabolism and defects in mitochondria.On the other hand,dipeptidyl peptidase-IV(DPP-IV)inhibitors such as sitagliptin and vildagliptin and ...; 关键词：SITAGLIPTIN VILDAGLIPTIN EXENDIN-4 Apoptosis Migration VIABILITY Chemo-sensitivity Mitochondrial biogenesis

Validated Chiral Ultra Fast Liquid Chromatographic Method for Quantitative Analysis of Enantiomeric Vildagliptin: 《American Journal of Analytical Chemistry》2021年第11期429-439,共11页Chinta Srinivas Husna Kanwal Qureshi Ciddi Veeresham; A rapid, accurate, and precise chiral Ultra fast liquid chromatography (UFLC) method was developed and validated for enantiomeric separation of racemic vildagliptin and S-vildagliptin according to the guideline...; 关键词：Standard Vildagliptin S-Vilda Ultra Fast Liquid Chromatography Method Development Validation

Drug interactions of dipeptidyl peptidase 4 inhibitors involving CYP enzymes and P-gp efflux pump: 《World Journal of Meta-Analysis》2019年第4期156-161,共6页Naina Mohamed Pakkir Maideen; Dipeptidyl peptidase 4(DPP4) inhibitors are oral antidiabetic drugs approved to manage type 2 diabetes mellitus. Saxagliptin is a substrate of CYP3A4/5 enzymes while other DPP4 inhibitors such as sitagliptin, linaglip...; 关键词：Drug interactions SITAGLIPTIN SAXAGLIPTIN LINAGLIPTIN Gemigliptin Teneligliptin VILDAGLIPTIN Anagliptin CYP3A4 P-GP EFFLUX pump

Mechanism Based Pharmacokinetic Pharmacodynamic Modeling of Vildagliptin as an Add-on to Metformin for Subjects with Type 2 Diabetes: 《Computer Modeling in Engineering & Sciences》2018年第2期153-171,共19页Marziyeh Eftekhari Omid Vahidi; Various drugs are used to maintain normoglycemia in subjects with type 2 diabetes mellitus.The combination of the drugs from different classes in one single tablet may enhance the effectiveness of the anti-diabetic dr...; 关键词：Pharmacokinetics PHARMACODYNAMICS mathematical modeling ANTI-DIABETIC drugs METFORMIN VILDAGLIPTIN

Clinical and Biochemical Changes in Polycystic Ovarian Syndrome Patients in Response to 3 Different Oral Hypoglycemic Drugs: A Double Blind Randomized Controlled Study: 《Open Journal of Obstetrics and Gynecology》2017年第1期117-128,共12页Ahmed S. El-Halwagy Adel A. Al-Gergawy Engy S. Eleslam Enaam S. Abd Elbar; Introduction: This study was done to evaluate other oral hypoglycemic medications;especially the new ones in the management of PCOS patients as alternatives to the standard medication used for this purpose Metformin. ...; 关键词：PCOS Pioglitazobe VILDAGLIPTIN METFORMIN

Vildagliptin vs sulfonylurea in Indian Muslim diabetes patients fasting during Ramadan: 《World Journal of Diabetes》2013年第6期358-364,共7页Abhijit Shete Aheson Shaikh K Javeed Nayeem Lily Rodrigues Mohamed Sheikamunadeen Sadiq Ali Parag Shah Rajiv Khanna Sarfaraj Majid Sabeer A Rasheed Shehla Shaikh Tawfiqur Rahman; Supported by Novartis Healthcare Private Limited,India; AIM:To compare the use of vildagliptin and sulfonylurea with or without metformin in Indian Muslim patients with type 2 diabetes mellitus,fasting during Ramadan.METHODS:This was a 4-wk,multicenter,non-interventional,o...; 关键词：Dipeptidyl-peptidase 4 inhibitors FASTING hypoglycemia SULFONYLUREA Type 2 DIABETES mellitus VILDAGLIPTIN

Dipeptidyl peptidase-4: A key player in chronic liver disease被引量：25: 《World Journal of Gastroenterology》2013年第15期2298-2306,共9页Minoru Itou Takumi Kawaguchi Eitaro Taniguchi Michio Sata; Dipeptidyl peptidase-4 (DPP-4) is a membrane-associated peptidase, also known as CD26. DPP-4 has widespread organ distribution throughout the body and exerts pleiotropic effects via its peptidase activity. A represent...; 关键词：INCRETIN Viral hepatitis Insulin resistance STEATOHEPATITIS Cancer SITAGLIPTIN VILDAGLIPTIN ALOGLIPTIN Teneligliptin LINAGLIPTIN

Vildagliptin-insulin combination improves glycemic control in Asians with type 2 diabetes被引量：6: 《World Journal of Diabetes》2013年第4期151-156,共6页Plamen Kozlovski James Foley Qing Shao Valentina Lukashevich Wolfgang Kothny; Supported by Novartis Pharma AG; AIM: To assess the efficacy and safety of vildagliptin 50 mg bid as add-on therapy to insulin in Asian patients with type 2 diabetes mellitus(T2DM).METHODS: This was a post hoc analysis of a subgroup of Asian patients...; 关键词：ASIAN DPP-4 inhibitor HYPOGLYCEMIA INSULIN Oral ANTIDIABETIC drug Type 2 diabetes VILDAGLIPTIN

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