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Non-coding RNAs as potential mediators of resistance to lung cancer immunotherapy and chemotherapy
《Oncology Research》2025年第5期1033-1054,共22页JIAHUI WANG HONGCHENG GE ZHENGYUAN YU LINGZHI WU 
Lung cancer is a common cause of cancer-related death globally.The majority of lung cancer patients initially benefit from chemotherapy and immunotherapy.However,as the treatment cycle progresses and the disease evolv...
关键词：Non-coding RNAs(ncRNAs) Lung cancer Drug resistance IMMUNOTHERAPY CHEMOTHERAPY Immune checkpoints Immune escape 
Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling
《Acta Pharmacologica Sinica》2025年第4期795-804,共10页Zheng-Jie Chia Hirushi Kumarapperuma Ruizhi Zhang Peter J.Little Danielle Kamato 
supported by a Future Leader Fellowship(106605)from the National Heart Foundation of Australia;HK and ZJC are supported by the Research Training Scholarship from the University of Queensland.
The Smad transcription factors are well known for their role at the core of transforming growth factor-β(TGF-β)signalling.However,recent evidence shows that the Smad transcription factors play a vital role downstrea...
关键词：transforming growth factor-beta receptor SMAD transactivation dependent GPCR signalling Akt phospho-Smad 
Exosomal mediators in sepsis and inflammatory organ injury:unraveling the role of exosomes in intercellular crosstalk and organ dysfunction
《Military Medical Research》2025年第2期264-284,共21页Ting Gong You-Tan Liu Jie Fan 
USA National Institutes of Health Grant(R01-HL-139547,to JF);USA VA Grants(1I01BX004838 and IK6BX004211,to JF);National Natural Science Foundation of China(82002087,to TG);Shenzhen Science and Technology Program(JCYJ20210324134602008,to TG)。
Sepsis,a severe systemic inflammatory response to infection,remains a leading cause of morbidity and mortality worldwide.Exosomes,as mediators of intercellular communication,play a pivotal role in the pathogenesis of ...
关键词：SEPSIS EXOSOMES Intercellular crosstalk Inflammation Biomarkers 
Strategies for Small Extracellular Vesicle-Based Cancer Immunotherapy
《Research》2025年第1期765-781,共17页Yundi Chen Shasha Tang Fengfeng Cai Yuan Wan 
supported by the National Cancer Institute(grants R01CA230339 and R37CA255948).
Extracellular vesicles(EVs)are lipid bilayer-enclosed vesicles released by cells.EVs encapsulate proteins and nucleic acids of their parental cell and efficiently deliver the cargo to recipient cells.These vesicles ac...
关键词：extracellular vesicles therapeutic agents liquid biopsy extracellular vesicles evs drug delivery mediators intercellular communication drug delivery vehiclestherapeutic agentsand cancer immunotherapy 
Curators and Mediators of Language,Content,Pedagogy,and Technology:Teachers’Expanding Roles in Fully-Online CLIL Contexts
《Chinese Journal of Applied Linguistics》2025年第1期50-69,155,共21页Yuliya Novitskaya Rebekah R.Gordon Douglas K.Hartman Curtis Green-Eneix 
funding from the U.S.-Kazakhstan University Partnerships program funded by the U.S.Mission to Kazakhstan and administered by American Councils[Award number SKZ100-19-CA-0149].
As world events have morphed teachers’roles within English medium of instruction(EMI)contexts to incorporate more online teaching practices,teachers’integration of digital tools has faced technological and curricula...
关键词：CLIL teacher professional development digital tools TPACK online teaching Kazakhstan 
Introducing ionic mediators to construct peak-splitting manganese oxide structures for efficient oxygen reduction reactions
《Journal of Materials Science & Technology》2024年第34期139-148,共10页Haoliang Ma Xiong Li Mengmeng Tian Lanlan Li Xiaofei Yu Xinghua Zhang Zunming Lu Xiaojing Yang 
supported by the Hebei Province Higher Edu-cation Scientific Research Project(No.JZX2024029)。
Manganese oxides have received extensive attention in Oxygen Reduction Reaction(ORR)research.How-ever,the poor electrical conductivity and oxygen adsorption capacity of manganese oxides limit their development,so it i...
关键词：Fuel cells ELECTROCHEMISTRY MANGANESE Structural distortion Ionically conductive medium 
Effect of epoxy macromolecules as interfacial mediators on the microstructure and physical properties of styrene butadiene rubber/talcum powder composites
《Resources Chemicals and Materials》2024年第4期247-257,共11页Qilai Wang Guangyang He Gang Gao Xianrong Shen Yixin Xiang 
financially supported the Key Research and Development Project of Anhui Province(2022a05020009);the Science and Technology Plan Project of Huangshan City(2021KC-05);the Engineering Research Project of Anhui Polytechnic University(HX-2021-09-007).
Poly(isoprene-co-glycidyl methacrylate)epoxy macromolecules were synthesized via reversible addition-fragmentation chain transfer(RAFT)polymerization to act as interfacial mediators between talcum powder(Talc)and styr...
关键词：Poly(isoprene-co-glycidyl methacrylate) Epoxy macromolecules Interfacial covalent bonds Viscoelastic properties 
Maternal Thyroid Hormones as Mediators between Phthalate Exposure and Neonatal Birth Weight:A Cross-Sectional Study from the Zunyi Birth Cohort
《Environment & Health》2024年第11期816-826,共11页Lin Tao Dengqing Liao Shimin Xiong Lulu Dai Yuan-zhong Zhou Xubo Shen 
funded by the National Key Research and Development Program of China(2018YF-C1004300,2018YFC1004302);Science&Technology Program of Guizhou Province(QKHHBZ[2020]3002,QKHPTRC-GCC[2022]039-1,QKHPTRC-CXTD[2022]014);Natural Science Foundation of Guizhou Province(QKH-J[2022]YB614);Science and Technology Plan Project of Zunyi City(ZKH-J(2021)294).
Studies have shown that exposure to phthalates can affect neonatal birth weight.However,epidemiological evidence on the mediating role of maternal thyroid hormones is limited.Therefore,this study,based on the Complian...
关键词：Phthalic acid esters(PAEs) Newborn birth weight(BBW) Thyroid hormones Linear regression model(LRM) Bayesian kernel-mechanism regression(BKMR) Structural equation modeling(SEM) 
Virtual Reality and the Metaverse as Educational and Technological Mediators for Medical and Scientific Education
《US-China Education Review(A)》2024年第10期645-654,共10页Stefano Bonometti Letizia Ferri Antonio Montagnoli Annalisa Grimaldi Peter Beatrice Andrea Moriondo Leonardo Iomini 
Virtual learning simulations are gaining prominence as a supplement to traditional teaching methods,offering several educational advantages.These simulations facilitate access to advanced training equipment and immers...
关键词：head-mounted displays high education blended learning 
Defective MnO_(2) functional separator coating as effective polysulfide mediators for lithium–sulfur batteries
《Tungsten》2024年第3期536-543,共8页Yan-Qi Feng Qiong-Qiong Lu Hui Liu 
the financial supports from the Joint Fund of Henan Province Science and Technology R&D Program(225200810093);the Startup Research of Henan Academy of Sciences(231817001);financially supports from the National Natural Science Foundation of China(51272147);the Natural Science Foundation of Shaanxi Province(2015JM5208);the Graduate Innovation Found of Shaanxi University of Science and Technology and Scientific Research Project of Chengdu Technological University(2023RC001);supported by the National Key R&D Program of China(2019YFC1520100)。
Advanced energy storage systems are in urgent need nowadays due to the rising demand in mobile devices and electric vehicles[1].Lithium–sulfur(Li–S)batteries are intensively studied due to the high theoretical speci...
关键词：LITHIUM COATING SULFUR 
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