Synthesis of N-alkyl substituted iminosugars from D-ribose  

作　　者：Haibo Wang Yang Pan Qin Tang Wei Zou Huawu Shao 

机构地区：[1]Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China [2]Institute for Biological Sciences, National Research Council of Canada, Ottawa KIA OR6, Canada [3]zhejiang Hongyuan Pharmaceutical Co., Ltd., Linhai 317000, China [4]Graduate School of Chinese Academy of Sciences, Belting 100049, China

出　　处：《Chinese Chemical Letters》2018年第1期73-75,共3页中国化学快报（英文版）

基　　金：supported by the Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Programme of Chinese Academy of Sciences(No. ZSTH-006);the National Natural Science Foundation of China(Nos. 21372215 and 21772192);Chinese Academy of Sciences(No.KFJ-SW-STS-143-1)

摘　　要：An effective and facile method for the synthesis of N-alkylated hydroxylpyrrolidine and hydroxylpiper- idine is described, A number of N-alkyl substituted iminosugars were prepared using iodine-induced intramolecular cyclization of acyclic alkenylamines as key step.An effective and facile method for the synthesis of N-alkylated hydroxylpyrrolidine and hydroxylpiper- idine is described, A number of N-alkyl substituted iminosugars were prepared using iodine-induced intramolecular cyclization of acyclic alkenylamines as key step.

关 键 词：lminosugar PYRROLIDINE PIPERIDINE GLYCOSIDASE D-RIBOSE 

分 类 号：O6[理学—化学]