GLYCOSIDASE

作品数：14被引量：24H指数：3
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相关领域：生物学医药卫生更多>>
相关机构：淡江大学更多>>
相关期刊：《Chinese Herbal Medicines》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《Science Bulletin》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划福建省自然科学基金更多>>
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OsPPG encodes a pseudouridine-5'-phosphate glycosidase and regulates rice spikelet development
《The Crop Journal》2024年第3期698-708,共11页Rui Chen Dagang Tian Yarong Lin Jiaqing Huang Qinqin Yang Yupei Li Huaqing Liu Shaohua Yang Jingyang Chen Shufen Zhou Feng Wang Shubiao Zhang 
partially supported by the Key Program of the National Natural Science of Fujian Province(2022J02010);Science and Technology Project of State Administration of Science,Technology and Industry for National Defense,Seed Innovation and Industrialization Project of Fujian Province(zycxny2021003);Fujian Province Public Welfare Scientific Research Program(2016R1018-8)。
Florets are the basic structural units of spikelets,and their morphogenesis determines the yield and quality of rice grains.However,whether and how pseudouridine-5’-phosphate glycosidase participates in rice spikelet...
关键词：OsPPG Reproductive regulation Spikelet development RICE 
Biological investigation of phenyl benzoate, benzophenone, and xanthone compounds
《Journal of Chinese Pharmaceutical Sciences》2022年第10期738-745,共8页Beidou Zhou Chun Lei Xuemei Liao Hang Zhu Zhipeng Ruan Yuanyuan Fang Guifen Xu Yuli Chen 
Natural Science Foundation of Fujian Province (Grant No. 2022J011158);Putian City Science and Technology Plan Project (Grant No. 2021S2001-9);Fujian Provincial Key Laboratory of Innovative Drug Target Research (Grant No. FJ-YW-2021KF01)。
In the present study, we evaluated the antitumor, anti-tyrosinase, anti-pancreatic lipase, antibacterial, antifungal, and anti-α-glycosidase activities for all or a subset of 20 known compounds. They included 8 pheny...
关键词：Phenyl benzoate BENZOPHENONE XANTHONE ANTIBACTERIAL ANTIFUNGAL α-Glycosidase 
Progress and mechanism of breaking glycoconjugates by glycosidases in skin for promoting unhairing and fiber opening-up in leather manufacture.A review被引量：6
《Journal of Leather Science and Engineering》2020年第1期113-128,共16页Fengxiang Luo Xiang Zhong Mengchu Gao Biyu Peng Zhongzhen Long 
the financial support from the National Key R&D Program of China(2017YFB0308402).
The glycoconjugates,herein glyco-proteins,existing in animal skins are closely related to the effectiveness of unhairing and fiber opening-up.Glycosidases have been used in leather making processes to reduce pollutant...
关键词：Glycosaminoglycan Proteoglycan GLYCOSIDASE Unhairing Fiber opening-up 
Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism被引量：1
《Acta Pharmacologica Sinica》2020年第7期995-1004,共10页Austin T Ryan Anunay J Pulukuri Maryam Davaritouchaee Armina Abbasi Aaron T Hendricksen Larissa K Opp Anthony J Burt Amy E Nielsen Rock J Mancini 
supported by the National Cancer Institute of the National Institutes of Health under Award Number 1R01CA234115;supported by NIH RR0631401;RR12948;NSF CHE-9115282;DBI-9604689;the Murdock Charitable Trust;private donors Don and Marianna Matteson.
We have recently developed an enzyme-directed immunostimulant(EDI)prodrug motif,which is metabolized to active immunostimulant by cancer cells and,following drug efflux,activates nearby immune cells,resulting in immun...
关键词：cancer immunotherapy drug efflux GLYCOSIDASE imidazoquinoline Toll-like receptor RESIQUIMOD 
Chemical constituents from acid hydrolyzates of Panax quinquefolius total saponins and their inhibition activity to α-glycosidase and protein tyrosine phosphatase 1B被引量：4
《Chinese Herbal Medicines》2020年第2期195-199,共5页Si-wen Han Sheng-ming Shi Yu-xiao Zou Zhi-cheng Wang Yan-qun Wang Lin Shi Ting-cai Yan 
supported by the National Natural Science Foundation of China(No.81602983)。
Objective:To investigate the hypoglycemic components from the acid hydrolyzates of Panax quinquefolius total saponins,and screen the active compounds by in vitro inhibitory activities toα-glycosidase enzymes and prot...
关键词：Panax quinquefolius L total saponins acid hydrolysis hypoglycemic effect 
Synthesis of N-alkyl substituted iminosugars from D-ribose
《Chinese Chemical Letters》2018年第1期73-75,共3页Haibo Wang Yang Pan Qin Tang Wei Zou Huawu Shao 
supported by the Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Programme of Chinese Academy of Sciences(No. ZSTH-006);the National Natural Science Foundation of China(Nos. 21372215 and 21772192);Chinese Academy of Sciences(No.KFJ-SW-STS-143-1)
An effective and facile method for the synthesis of N-alkylated hydroxylpyrrolidine and hydroxylpiper- idine is described, A number of N-alkyl substituted iminosugars were prepared using iodine-induced intramolecular ...
关键词：lminosugar PYRROLIDINE PIPERIDINE GLYCOSIDASE D-RIBOSE 
Synthesis and glycosidase inhibition of C-7 modified casuarine derivatives
《Chinese Chemical Letters》2017年第8期1701-1704,共4页Bin Cheng Yuki Hirokami Yi-Xian Li Atsushi Kato Yue-Mei Jia Chu-Yi Yu 
Financial support from the National Natural Science Foundation of China(Nos.21642012 and 21272240);National Science and Technology Major Projects for“Major New Drugs Innovation and Development”(No.2013ZX09508104);National Engineering Research Center for Carbohydrate Synthesis of Jiangxi Normal University;supported in part by a Grant-in-Aid for Scientific Research(C)(No.26460143)(AK)from the Japanese Society for the Promotion of Science(JSPS)
A series of C-7 modified analogues of casuarine have been synthesized from sugar-derived nitrone and assayed against various glycosidases. Introduction of C-7 aminomethyl or amide group led to sharp decrease of the in...
关键词：Nitrone 1.3-Dipolar cycloaddition Ammonolysis Glycosidase inhibitors Polyhydroxylated pyrrolizidines 
In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine被引量：11
《Acta Pharmacologica Sinica》2017年第3期351-361,共11页Na YANG Run-bin SUN Xing-long CHEN Le ZHEN Chun GE Yu-qing ZHAO Jun HE Jian-liang GENG Jia-hua GUO Xiao-yi YU Fei FEI Si-qi FENG Xuan-xuan ZHU Hong-bo WANG Feng-hua FU Ji-ye AA Guang-ji WANG 
Acknowledgements This study was financially supported by the National Natural Science Foundation of China （No_ 81573495, 81530098）, the Key Technology Projects of China ＂Creation of New Drugs＂ （No_ 2015ZX09501001）, the Project for Jiangsu Province Key Lab of Drug Metabolism and Pharmacokinetics （No BM2012012） and the Project of the University Collaborative Innovation Center of Jiangsu Province （Modern Chinese Medicine Center and Biological Medicine Center）.
Berberrubine （BRB） is the primary metabolite of berberine （BBR） that has shown a stronger glucose-lowering effect than BBR in vivo. On the other hand, BRB is quickly and extensively metabolized into berberrubine-9...
关键词：HYPERGLYCEMIA glucose-lowering effect BERBERINE berberrubine GLUCURONIDE （x-glycosidase HFD-induced hyperglycemiamodel of C57BL/6 mice human normal liver cell line 1_-02 PHARMACOKINETICS 
Biphenyls from aerial parts of Ribes takare
《Chinese Chemical Letters》2014年第1期127-130,共4页Xiao-Zhen Chen Sheng-Ming Lu Guo-You Li Wei Jiao Tian-Fang Huang Tao Yang Dong-Mei Fang 
supported financially by National Natural Science Foundation of China(Nos.21002098 and 20932007);‘Western Light’ Research Program from Chinese Academy of Sciences(No.Y1C1011);National New Drug Innovation Major Project of China(No.2011ZX09307-002-02)
Three new biphenyls, 4,7,8-trimethoxy-2,3-methylenedioxydibenzofuran （1）, 7-hydroxy-4,8- dimethoxy-2,3-methylenedioxydibenzofuran （2）, and 3＇,5-dimethoxy-3,4-methylenedioxybiphenyl （3）, along with eighteen know...
关键词：Biphenyl Ribes takare D. Don α-Glycosidase Inhibitory activity 
Novel 2-aryl-3,4,5-trihydroxypiperidines:Synthesis and glycosidase inhibition
《Chinese Chemical Letters》2013年第12期1059-1063,共5页Hui Zhao Wu-Bao Wang Shinpei Nakagawa Yue-Mei Jia Xiang-Guo Hu George W.J.Fleet Francis X.Wilson Robert J.Nash Atsushi Kato Chu-Yi Yu 
Financial support from National Basic Research Program of China (Nos. 2012CB822101 and 2011CB808603);the Natural Science Foundation of China (Nos. 21272240 and 21102149)
Three pairs of novel 2-aryl-3,4,5-trihydroxypiperidines （6-8 and their enantiomers）, the piperidine analogues of the pyrrolidine alkaloids radicamine A and radicamine B, were prepared from six- membered cyclic nitro...
关键词：2-Aryl polyhydroxylated piperidine lminosugars Radicamine mimics Glycosidase inhibitors 
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