A Novel One-Pot and Efficient Procedure for Synthesis of New Fused Uracil Derivatives for DNA Binding  

作　　者：Bothaina A. Mousa Ashraf H. Bayoumi Makarem M. Korraa Mohamed G. Assy Samar A. El-Kalyoubi 

机构地区：[1]Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Giza, Egypt [2]Department of Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt [3]Department of Organic Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt [4]Department of Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt

出　　处：《International Journal of Organic Chemistry》2015年第1期37-47,共11页有机化学国际期刊（英文）

摘　　要：Hydrazinolysis of 6-chloro-1-methyluracil followed by condensation of the product with different aromatic aldehyde gives the respective hydrazones which undergoes oxidative cyclization using thionyl chloride to obtain pyrazolo[3,4-d]pyrimidines in good yields. On the other hand, nitrosation of 6-aminouracils followed by the reaction with different arylidineanilines gives new xanthine derivatives. Finally, indenopyrrolopyrimidine and indenopteridine are obtained in good yields via the reaction of 6-aminouracils and 5,6-diaminouracil with ninhydrin respectively. The newly synthesized compounds show binding, chelation and fragmentation of the nucleic acid DNA.Hydrazinolysis of 6-chloro-1-methyluracil followed by condensation of the product with different aromatic aldehyde gives the respective hydrazones which undergoes oxidative cyclization using thionyl chloride to obtain pyrazolo[3,4-d]pyrimidines in good yields. On the other hand, nitrosation of 6-aminouracils followed by the reaction with different arylidineanilines gives new xanthine derivatives. Finally, indenopyrrolopyrimidine and indenopteridine are obtained in good yields via the reaction of 6-aminouracils and 5,6-diaminouracil with ninhydrin respectively. The newly synthesized compounds show binding, chelation and fragmentation of the nucleic acid DNA.

关 键 词：6-Chloro-1-methyluracil Pyrazolo[3 4-d]pyrimidines 6-Aminouracils XANTHINE Indenopyrrolopyrimidine and Indenopteridine 

分 类 号：O6[理学—化学]