Semi-Automated Synthesis of [F-18]FBAM, a Thiol Reactive Prosthetic Group, Using Continuous Flow Chemistry  

作　　者：Murthy R. Akula Srinivasa R. Marepally Lee T. Collier W. George Kabalka Murthy R. Akula;Srinivasa R. Marepally;Lee T. Collier;W. George Kabalka(Departments of Chemistry and Radiology, University of Tennessee, Knoxville, Tennessee, USA;Advion Biosystems, Ithaca, NY, USA)

机构地区：[1]Departments of Chemistry and Radiology, University of Tennessee, Knoxville, Tennessee, USA [2]Advion Biosystems, Ithaca, NY, USA

出　　处：《International Journal of Organic Chemistry》2016年第3期177-185,共9页有机化学国际期刊（英文）

摘　　要：[F-18]FBAM, a thiol reactive bifunctional agent, was successfully synthesized using continuous flow chemistry in a micro reactor that is part of Advion NanoTek Micro-fluidic Synthesizer. As the radiofluorination was carried out microfluidically, a very small amount of precursor was used and over all radiochemical yield was 38% ± 4% (n = 8, decay corrected) and the radiochemical purity was ≥98% with specific activity of 430 mC/μmol. The total reaction time including HPLC purification was 55 min that is 14 min more than manual synthesis and 6 min less than fully automated synthesis.[F-18]FBAM, a thiol reactive bifunctional agent, was successfully synthesized using continuous flow chemistry in a micro reactor that is part of Advion NanoTek Micro-fluidic Synthesizer. As the radiofluorination was carried out microfluidically, a very small amount of precursor was used and over all radiochemical yield was 38% ± 4% (n = 8, decay corrected) and the radiochemical purity was ≥98% with specific activity of 430 mC/μmol. The total reaction time including HPLC purification was 55 min that is 14 min more than manual synthesis and 6 min less than fully automated synthesis.

关 键 词：Bifunctional Agent MICRO-REACTOR 6-Bromohexnol RADIOFLUORINATION Appel Reaction 

分 类 号：O62[理学—有机化学]