RADIOFLUORINATION

作品数：4被引量：1H指数：1
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相关期刊：《Natural Science》《International Journal of Organic Chemistry》《Acta Pharmaceutica Sinica B》更多>>
相关基金：王宽诚敎育基金国家自然科学基金更多>>
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Peptides Radiofluorination: Main Methods and Highlights
《International Journal of Organic Chemistry》2022年第4期161-172,共12页Ana Carolina A. Bispo Fernanda A. F. Almeida Juliana B. Silva Marcelo Mamede 
Peptides have an important role in organism and its high quantity present in tumors leading to development of radiolabeled peptides for tumor-specific imaging. Once the traditional methodologies used for radiofluorina...
关键词：RADIOFLUORINATION RADIOLABELING PEPTIDES Prosthetic Groups FLUORINE-18 
Discovery of a highly specific ^(18)F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination
《Acta Pharmaceutica Sinica B》2022年第4期1963-1975,共13页Zhiwei Xiao Huiyi Wei Yi Xu Ahmed Haider Junjie Wei Shiyu Yuan Jian Rong Chunyu Zhao Guocong Li Weibin Zhang Huangcan Chen Yuefeng Li Lingling Zhang Jiyun Sun Shaojuan Zhang Hai-Bin Luo Sen Yan Qijun Cai Lu Hou Chao Che Steven H.Liang Lu Wang 
the support of K.C.Wong Education Foundation (China);financially supported by the National Natural Science Foundation of China (No.82071974);Shenzhen Basic Research Project (JCYJ20180503182116931, China);Guangdong Basic and Applied Basic Research Foundation (2020A1515011192, 2018A0303130052, China);Guangzhou Key Research Program on Brain Science (202007030008, China);the Fundamental Research Funds for the Central Universities (21619104, 21621051, China)
As a member of cyclic nucleotide phosphodiesterase(PDE)enzyme family,PDE10A is in charge of the degradation of cyclic adenosine(cAMP)and guanosine monophosphates(cGMP).While PDE10A is primarily expressed in the medium...
关键词：Phosphodiesterase 10A PET radioligand 18F Spirocyclic iodonium ylide Nonhuman primate Target occupancy 
Effect of Added Cu(OTf)<sub>2</sub>on the Cu(OTf)<sub>2</sub>(Py)<sub>4</sub>-Mediated Radiofluorination of Benzoyl and Phthaloylglycinates被引量：1
《Natural Science》2018年第3期125-133,共9页David W. Blevins George W. Kabalka Dustin R. Osborne Murthy R. Akula 
Cu(OTf)2(Py)4 mediated radiofluorination of the boronate esters of ethyl benzoyl and phthaloylglycinates (11 and 16) using 10 mol% of the copper complex following the literature procedure did not provide the fluorinat...
关键词：Glycinates BORONATE Esters Gorlos-Phos RADIOFLUORINATION Copper Triflate 
Semi-Automated Synthesis of [F-18]FBAM, a Thiol Reactive Prosthetic Group, Using Continuous Flow Chemistry
《International Journal of Organic Chemistry》2016年第3期177-185,共9页Murthy R. Akula Srinivasa R. Marepally Lee T. Collier W. George Kabalka 
[F-18]FBAM, a thiol reactive bifunctional agent, was successfully synthesized using continuous flow chemistry in a micro reactor that is part of Advion NanoTek Micro-fluidic Synthesizer. As the radiofluorination was c...
关键词：Bifunctional Agent MICRO-REACTOR 6-Bromohexnol RADIOFLUORINATION Appel Reaction 
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