Green Synthesis of Novel 5-Arylazo-2-[(2S, 3S, 4R, 5R)-3, 4, 5-Trihydroxy-6-(Hydroxymethyl) Tetrahydro-2H-Pyran-2-Yloxy]-4, 6-Dimethyl 3-Nicotinonitrile  

作　　者：Magda H. Abdellattif Mohamed Mohamed Helmy Arief Adel A. H. Abdel-Rahman Abdel-Aleem H. Abdel Aleem Abdel Moneam Farag Eissa 

机构地区：[1]Deanship of Scientific Research, Taif University, Alhawaya, Taif, KSA [2]Chemistry Department, Faculty of Science, Benha University, Benha, Egypt [3]Chemistry Department, Faculty of Science, Menaufia University, Shebin Elkom, Egypt

出　　处：《International Journal of Organic Chemistry》2017年第4期389-402,共14页有机化学国际期刊（英文）

摘　　要：Introduction: Pyridone derivatives played important roles in the last decade to approach many and different functionalities, especially as antitumor, antibacterial, anti-fungal, and many of pharmacological activities. Methodology: Novel compounds of 5-Arylazo-2-[(substituted)-3, 4, 5-trihydroxy-6-(hydroxymethyl) tetrahydro-2H-pyran-2-yloxy]-4, 6-dimethylnicotinonitrile, (3a-e), generally called (fluroarylazopyridine glucosides) were synthesised via green protocol, microwave. Results: The compounds were investigated by (IR, 1HNMR, 13CNMR and mass spectrometry). Where some of pharmacological activities like antibacterial and antifungal studies had been investigated and characterized. It was found that 3a-d had characterized by high activities as antibacterial and antifungal. Where microwave synthetic methods were more efficient, gave higher products quantity, and more saving for time requirement and for using of much more solvents.Introduction: Pyridone derivatives played important roles in the last decade to approach many and different functionalities, especially as antitumor, antibacterial, anti-fungal, and many of pharmacological activities. Methodology: Novel compounds of 5-Arylazo-2-[(substituted)-3, 4, 5-trihydroxy-6-(hydroxymethyl) tetrahydro-2H-pyran-2-yloxy]-4, 6-dimethylnicotinonitrile, (3a-e), generally called (fluroarylazopyridine glucosides) were synthesised via green protocol, microwave. Results: The compounds were investigated by (IR, 1HNMR, 13CNMR and mass spectrometry). Where some of pharmacological activities like antibacterial and antifungal studies had been investigated and characterized. It was found that 3a-d had characterized by high activities as antibacterial and antifungal. Where microwave synthetic methods were more efficient, gave higher products quantity, and more saving for time requirement and for using of much more solvents.

关 键 词：Green CHEMISTRY Green Protocol PYRIDONES Fluroazo COMPOUNDS Microwave 

分 类 号：O6[理学—化学]