Safe Hydroformylation of Aliphatic Alkene in a Flow Reactor  

作　　者：Hisashi Masui Eiki Honda Sakura Niitsu Mitsuru Shoji Takashi Takahashi 

机构地区：[1]Department of Pharmaceutical Sciences, Yokohama University of Pharmacy, Yokohama, Japan

出　　处：《International Journal of Organic Chemistry》2018年第1期135-141,共7页有机化学国际期刊（英文）

摘　　要：Despite hydroformylation being a very efficient method for the transformation of alkenes, it is not commonly employed in laboratories owing to the flammable/toxic nature of hydrogen and carbon monoxide gases and the necessity of high-pressure equipment in a batch system. Flow chemistry often raises the safety profiles against high-pressure and toxic gases because the diameter of the flow reactor is small. Herein, we show that aliphatic alkenes can be safely hydroformylated in a flow reactor. In our flow method, although the target hydroformylated product was obtained in a low yield (19%), toxic gases were safely treated using a flow reactor. Better yields could possibly be achieved by recycling of the unreacted alkene.Despite hydroformylation being a very efficient method for the transformation of alkenes, it is not commonly employed in laboratories owing to the flammable/toxic nature of hydrogen and carbon monoxide gases and the necessity of high-pressure equipment in a batch system. Flow chemistry often raises the safety profiles against high-pressure and toxic gases because the diameter of the flow reactor is small. Herein, we show that aliphatic alkenes can be safely hydroformylated in a flow reactor. In our flow method, although the target hydroformylated product was obtained in a low yield (19%), toxic gases were safely treated using a flow reactor. Better yields could possibly be achieved by recycling of the unreacted alkene.

关 键 词：HYDROFORMYLATION Flow Synthesis ALKENE Carbon MONOXIDE ALDEHYDE 

分 类 号：O6[理学—化学]