A New Process of Synthesizing Anandamide Derivatives from Arachidonic Acid in the Presence of Boron Catalyst  

作　　者：Mohammad Al-Masum Linda Quinones Mohammad Al-Masum;Linda Quinones(Department of Chemistry, Tennessee State University, Nashville, TN, USA)

机构地区：[1]Department of Chemistry, Tennessee State University, Nashville, TN, USA

出　　处：《International Journal of Organic Chemistry》2024年第4期128-134,共7页有机化学国际期刊(英文)

摘　　要：Anandamide is part of the cannabinoid group and functions as a neurotransmitter. Anandamide plays a role in depression, pain, appetite, memory, and fertility. Since it is well documented that anandamide analog behaves as probes of the cannabinoid receptor, it is of great interest to find a new method of making new series of anandamide derivatives. Dennis Hall and his group recently reported a direct amidation process of carboxylic acid by ortho-iodo boronic acid. Using ortho-iodo boronic acid as a catalyst, we explore the amidation of arachidonic acid under microwave heating and synthesize anandamide derivatives in high yields.Anandamide is part of the cannabinoid group and functions as a neurotransmitter. Anandamide plays a role in depression, pain, appetite, memory, and fertility. Since it is well documented that anandamide analog behaves as probes of the cannabinoid receptor, it is of great interest to find a new method of making new series of anandamide derivatives. Dennis Hall and his group recently reported a direct amidation process of carboxylic acid by ortho-iodo boronic acid. Using ortho-iodo boronic acid as a catalyst, we explore the amidation of arachidonic acid under microwave heating and synthesize anandamide derivatives in high yields.

关 键 词：ANANDAMIDE CROSS-COUPLING MICROWAVE Alcohol Amines 

分 类 号：O62[理学—有机化学]