A Novel Antibacterial Dental Resin Composite  

作　　者：Yiming Weng Voon J. Chong Leah Howard Ruijie Huang Richard L. Gregory Dong Xie 

机构地区：[1]Department of Biomedical Engineering, Purdue School of Engineering and Technology Indiana University-Purdue University at Indianapolis, Indianapolis, USA [2]Department of Oral Biology, School of Dentistry, Indiana University Indianapolis, USA

出　　处：《Journal of Biomaterials and Nanobiotechnology》2012年第2期130-135,共6页生物材料与纳米技术（英文）

摘　　要：This study reports the synthesis and evaluation of a novel furanone-containing antibacterial resin composite. Compres-sive strength (CS) and S. mutans viability were used to evaluate the mechanical strength and antibacterial activity of the composites. With 5% to 30% addition of the furanone derivative, the composite showed no change in CS but a significant antibacterial activity with a 16% - 68% reduction in the S. mutans viability. Further, the antibacterial activity of the modified composite was not affected by human saliva. The aging study implies that the modified composite may have a long-lasting antibacterial function. Within the limitations of this study, it appears that this experimental resin composite may potentially be developed into a clinically attractive dental restorative due to its high mechanical strength and antibacterial function.This study reports the synthesis and evaluation of a novel furanone-containing antibacterial resin composite. Compres-sive strength (CS) and S. mutans viability were used to evaluate the mechanical strength and antibacterial activity of the composites. With 5% to 30% addition of the furanone derivative, the composite showed no change in CS but a significant antibacterial activity with a 16% - 68% reduction in the S. mutans viability. Further, the antibacterial activity of the modified composite was not affected by human saliva. The aging study implies that the modified composite may have a long-lasting antibacterial function. Within the limitations of this study, it appears that this experimental resin composite may potentially be developed into a clinically attractive dental restorative due to its high mechanical strength and antibacterial function.

关 键 词：FURANONE DERIVATIVE ANTIBACTERIAL RESIN Composite CS S. MUTANS VIABILITY 

分 类 号：R73[医药卫生—肿瘤]